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Structure paper

TitleStructure of trypanosome coat protein VSGsur and function in suramin resistance.
Journal, issue, pagesNat Microbiol, Vol. 6, Page 392-400, Year 2021
Publish dateMay 30, 2020 (structure data deposition date)
AuthorsZeelen, J. / van Straaten, M. / Verdi, J. / Hempelmann, A. / Hashemi, H. / Perez, K. / Jeffrey, P.D. / Halg, S. / Wiedemar, N. / Maser, P. ...Zeelen, J. / van Straaten, M. / Verdi, J. / Hempelmann, A. / Hashemi, H. / Perez, K. / Jeffrey, P.D. / Halg, S. / Wiedemar, N. / Maser, P. / Papavasiliou, F.N. / Stebbins, C.E.
External linksNat Microbiol / PubMed:33462435
MethodsX-ray diffraction
Resolution1.38 - 1.92 Å
Structure data

PDB-6z79:
Variant Surface Glycoprotein VSGsur, I3C ("Magic Triangle") derivative used for phasing of the structure and subsequently as a model for molecular replacement of native, mutants, and drug soaks.
Method: X-RAY DIFFRACTION / Resolution: 1.92 Å

PDB-6z7b:
Variant Surface Glycoprotein VSGsur bound to suramin
Method: X-RAY DIFFRACTION / Resolution: 1.86 Å

PDB-6z7c:
Variant Surface Glycoprotein VSGsur mutant H122A
Method: X-RAY DIFFRACTION / Resolution: 1.64 Å

PDB-6z7d:
Variant Surface Glycoprotein VSGsur mutant H122A soaked in 0.77 mM Suramin.
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-6z7e:
Variant Surface Glycoprotein VSGsur mutant H122A soaked in 7.7 mM suramin
Method: X-RAY DIFFRACTION / Resolution: 1.663 Å

PDB-6z8g:
Crystal structure of VSG13 soaked in 0.5 M used to phase VSG13 to solve the structure.
Method: X-RAY DIFFRACTION / Resolution: 1.56 Å

PDB-6z8h:
Crystal structure of Variant Surface Glycoprotein VSG13
Method: X-RAY DIFFRACTION / Resolution: 1.38 Å

Chemicals

ChemComp-I3C:
5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid

ChemComp-HOH:
WATER

ChemComp-SVR:
8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON / medication*YM

ChemComp-BR:
BROMIDE ION

ChemComp-SO4:
SULFATE ION

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • trypanosoma brucei rhodesiense (eukaryote)
  • trypanosoma brucei (eukaryote)
KeywordsMEMBRANE PROTEIN / Variant surface glycoprotein Suramin Trypanosomiasis Drug resistance Glycosylation Magic Triangle I3C / Variant surface glycoprotein Suramin Trypanosomiasis Drug resistance Glycosylation VSG / Variant Surface Glycoprotein / Immune Recognition / Immune Evasion / Trypanosomiasis

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