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Structure paper

TitleStructure and activity of PPX/GppA homologs from Escherichia coli and Helicobacter pylori.
Journal, issue, pagesFebs J., Vol. 287, Page 1865-1885, Year 2020
Publish dateJun 15, 2019 (structure data deposition date)
AuthorsSong, H. / Dharmasena, M.N. / Wang, C. / Shaw, G.X. / Cherry, S. / Tropea, J.E. / Jin, D.J. / Ji, X.
External linksFebs J. / PubMed:31679177
MethodsX-ray diffraction
Resolution1.7 - 2.9 Å
Structure data

PDB-6pbz:
Crystal structure of Escherichia coli GppA
Method: X-RAY DIFFRACTION / Resolution: 2.475 Å

PDB-6pc0:
Crystal structure of Helicobacter pylori PPX/GppA
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-6pc1:
Crystal structure of Helicobacter pylori PPX/GppA (E143A) in complex with ppGpp
Method: X-RAY DIFFRACTION / Resolution: 2.76 Å

PDB-6pc2:
Crystal structure of Helicobacter pylori PPX/GppA in complex with GNP
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-6pc3:
Crystal structure of Helicobacter pylori PPX/GppA in complex with GSP
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-MLT:
D-MALATE

ChemComp-LMR:
(2S)-2-hydroxybutanedioic acid

ChemComp-G4P:
GUANOSINE-5',3'-TETRAPHOSPHATE

ChemComp-PO4:
PHOSPHATE ION

ChemComp-MG:
Unknown entry

ChemComp-GNP:
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / GppNHp, GMPPNP, energy-carrying molecule analogue*YM

ChemComp-GSP:
5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE

ChemComp-K:
Unknown entry

ChemComp-TS6:
Monothiophosphate

Source
  • escherichia coli (strain k12) (bacteria)
  • helicobacter pylori (strain g27) (bacteria)
KeywordsHYDROLASE / pppGpp / ppGpp / PPX / GppA / Polyphosphate

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