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-Structure paper
Title | An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering. |
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Journal, issue, pages | Nat Commun, Vol. 14, Page 6091-6091, Year 2023 |
Publish date | Oct 31, 2018 (structure data deposition date) |
![]() | Cui, G. / Botuyan, M.V. / Drane, P. / Hu, Q. / Bragantini, B. / Thompson, J.R. / Schuller, D.J. / Detappe, A. / Perfetti, M.T. / James, L.I. ...Cui, G. / Botuyan, M.V. / Drane, P. / Hu, Q. / Bragantini, B. / Thompson, J.R. / Schuller, D.J. / Detappe, A. / Perfetti, M.T. / James, L.I. / Frye, S.V. / Chowdhury, D. / Mer, G. |
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Methods | X-ray diffraction |
Resolution | 1.624 - 3.79 Å |
Structure data | ![]() PDB-6mxx: ![]() PDB-6mxy: ![]() PDB-6mxz: ![]() PDB-6my0: ![]() PDB-8u4u: |
Chemicals | ![]() ChemComp-PO4: ![]() ChemComp-K6P: ![]() ChemComp-FMT: ![]() ChemComp-HOH: ![]() ChemComp-K6M: ![]() ChemComp-K6S: |
Source |
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![]() | PROTEIN BINDING / 53BP1 / Tandem Tudor domains / Small molecule inhibitor / DNA damage response / Class switch recombination / Tudor domain / DNA double-strand breaks / SIGNALING PROTEIN / DNA double-strand break repair / non-homologous end joining / homologous recombination / chromatin-binding protein / engineered protein |