Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
Journal, issue, pages	Iscience, Vol. 23, Page 101727-101727, Year 2020
Publish date	Jun 24, 2019 (structure data deposition date)
Authors	Kamata, S. / Oyama, T. / Saito, K. / Honda, A. / Yamamoto, Y. / Suda, K. / Ishikawa, R. / Itoh, T. / Watanabe, Y. / Shibata, T. ...Kamata, S. / Oyama, T. / Saito, K. / Honda, A. / Yamamoto, Y. / Suda, K. / Ishikawa, R. / Itoh, T. / Watanabe, Y. / Shibata, T. / Uchida, K. / Suematsu, M. / Ishii, I.
External links	Iscience / PubMed:33205029
Methods	X-ray diffraction
Resolution	1.23 - 3.301 Å
Structure data	PDB-6kax: X-ray structure of human PPARalpha ligand binding domain-intrinsic fatty acid (E. coli origin) co-crystals obtained by cross-seeding Method: X-RAY DIFFRACTION / Resolution: 1.23 Å PDB-6kay: X-ray structure of human PPARalpha ligand binding domain-GW7647 co-crystals obtained by soaking Method: X-RAY DIFFRACTION / Resolution: 1.735 Å PDB-6kaz: X-ray structure of human PPARalpha ligand binding domain-pemafibrate co-crystals obtained by soaking Method: X-RAY DIFFRACTION / Resolution: 1.48 Å PDB-6kb0: X-ray structure of human PPARalpha ligand binding domain-5,8,11,14-eicosatetraynoic acid (ETYA) co-crystals obtained by soaking Method: X-RAY DIFFRACTION / Resolution: 1.35 Å PDB-6kb1: X-ray structure of human PPARalpha ligand binding domain-tetradecylthioacetic acid (TTA) co-crystals obtained by soaking Method: X-RAY DIFFRACTION / Resolution: 1.25 Å PDB-6kb2: X-ray structure of human PPARalpha ligand binding domain-Wy14643 co-crystals obtained by soaking Method: X-RAY DIFFRACTION / Resolution: 1.95 Å PDB-6kb3: X-ray structure of human PPARalpha ligand binding domain-GW7647 co-crystals obtained by delipidation and cross-seeding Method: X-RAY DIFFRACTION / Resolution: 1.45 Å PDB-6kb4: X-ray structure of human PPARalpha ligand binding domain-pemafibrate co-crystals obtained by delipidation and cross-seeding Method: X-RAY DIFFRACTION / Resolution: 1.42 Å PDB-6kb5: X-ray structure of human PPARalpha ligand binding domain-5,8,11,14-eicosatetraynoic Acid (ETYA) co-crystals obtained by delipidation and cross-seeding Method: X-RAY DIFFRACTION / Resolution: 1.95 Å PDB-6kb6: X-ray structure of human PPARalpha ligand binding domain-tetradecylthioacetic acid (TTA) co-crystals obtained by delipidation and cross-seeding Method: X-RAY DIFFRACTION / Resolution: 1.431 Å PDB-6kb7: X-ray structure of human PPARalpha ligand binding domain-Wy14643 co-crystals obtained by delipidation and cross-seeding Method: X-RAY DIFFRACTION / Resolution: 2.14 Å PDB-6kb8: X-ray structure of human PPARalpha ligand binding domain-GW7647 co-crystals obtained by cross-seeding Method: X-RAY DIFFRACTION / Resolution: 1.47 Å PDB-6kb9: X-ray structure of human PPARalpha ligand binding domain-pemafibrate co-crystals obtained by cross-seeding Method: X-RAY DIFFRACTION / Resolution: 1.55 Å PDB-6kba: X-ray structure of human PPARalpha ligand binding domain-Wy14643 co-crystals obtained by co-crystallization Method: X-RAY DIFFRACTION / Resolution: 1.82 Å PDB-6kyp: X-ray structure of human PPARalpha ligand binding domain-GW9662-clofibric acid co-crystals obtained by delipidation and co-crystallization Method: X-RAY DIFFRACTION / Resolution: 2.86 Å PDB-6l36: X-ray structure of human PPARalpha ligand binding domain-GW9662-fenofibric acid co-crystals obtained by delipidation and co-crystallization Method: X-RAY DIFFRACTION / Resolution: 3.301 Å PDB-6l37: X-ray structure of human PPARalpha ligand binding domain-GW9662-ciprofibrate co-crystals obtained by delipidation and co-crystallization Method: X-RAY DIFFRACTION / Resolution: 2.91 Å PDB-6l38: X-ray structure of human PPARalpha ligand binding domain-GW9662-gemfibrozil co-crystals obtained by delipidation and co-crystallization Method: X-RAY DIFFRACTION / Resolution: 2.761 Å PDB-6lx4: X-ray structure of human PPARalpha ligand binding domain-fenofibric acid co-crystals obtained by delipidation and co-crystallization Method: X-RAY DIFFRACTION / Resolution: 2.13 Å PDB-6lx5: X-ray structure of human PPARalpha ligand binding domain-ciprofibrate co-crystals obtained by delipidation and co-crystallization Method: X-RAY DIFFRACTION / Resolution: 1.87 Å PDB-6lx6: X-ray structure of human PPARalpha ligand binding domain-palmitic acid co-crystals obtained by delipidation and cross-seeding Method: X-RAY DIFFRACTION / Resolution: 1.3 Å PDB-6lx7: X-ray structure of human PPARalpha ligand binding domain-stearic acid co-crystals obtained by delipidation and cross-seeding Method: X-RAY DIFFRACTION / Resolution: 1.41 Å PDB-6lx8: X-ray structure of human PPARalpha ligand binding domain-oleic acid co-crystals obtained by delipidation and cross-seeding Method: X-RAY DIFFRACTION / Resolution: 1.54 Å PDB-6lx9: X-ray structure of human PPARalpha ligand binding domain-arachidonic acid co-crystals obtained by delipidation and cross-seeding Method: X-RAY DIFFRACTION / Resolution: 1.4 Å PDB-6lxa: X-ray structure of human PPARalpha ligand binding domain-eicosapentaenoic acid (EPA) co-crystals obtained by delipidation and cross-seeding Method: X-RAY DIFFRACTION / Resolution: 1.23 Å PDB-6lxb: X-ray structure of human PPARalpha ligand binding domain-saroglitazar co-crystals obtained by soaking Method: X-RAY DIFFRACTION / Resolution: 2.36 Å PDB-6lxc: X-ray structure of human PPARalpha ligand binding domain-saroglitazar co-crystals obtained by delipidation and cross-seeding Method: X-RAY DIFFRACTION / Resolution: 2.03 Å PDB-7bpy: X-ray structure of human PPARalpha ligand binding domain-clofibric acid-SRC1 coactivator peptide co-crystals obtained by delipidation and co-crystallization Method: X-RAY DIFFRACTION / Resolution: 2.09 Å PDB-7bpz: X-ray structure of human PPARalpha ligand binding domain-bezafibrate-SRC1 coactivator peptide co-crystals obtained by soaking Method: X-RAY DIFFRACTION / Resolution: 2.43 Å PDB-7bq0: X-ray structure of human PPARalpha ligand binding domain-fenofibric acid-SRC1 coactivator peptide co-crystals obtained by delipidation and co-crystallization Method: X-RAY DIFFRACTION / Resolution: 1.771 Å PDB-7bq1: X-ray structure of human PPARalpha ligand binding domain-intrinsic fatty acid (E. coli origin)-SRC1 coactivator peptide co-crystals obtained by co-crystallization Method: X-RAY DIFFRACTION / Resolution: 1.521 Å PDB-7bq2: X-ray structure of human PPARalpha ligand binding domain-pemafibrate-SRC1 coactivator peptide co-crystals obtained by soaking Method: X-RAY DIFFRACTION / Resolution: 1.52 Å PDB-7bq3: X-ray structure of human PPARalpha ligand binding domain-GW7647-SRC1 coactivator peptide co-crystals obtained by delipidation and co-crystallization Method: X-RAY DIFFRACTION / Resolution: 1.98 Å PDB-7bq4: X-ray structure of human PPARalpha ligand binding domain-eicosapentaenoic acid (EPA)-SRC1 coactivator peptide co-crystals obtained by delipidation and co-crystallization Method: X-RAY DIFFRACTION / Resolution: 1.62 Å
Chemicals	ChemComp-GOL: GLYCEROL / Glycerol ChemComp-PLM: PALMITIC ACID / Palmitic acid ChemComp-HOH: WATER / Water ChemComp-2VN: 2-[(4-{2-[(4-cyclohexylbutyl)(cyclohexylcarbamoyl)amino]ethyl}phenyl)sulfanyl]-2-methylpropanoic acid ChemComp-P7F: (2~{R})-2-[3-[[1,3-benzoxazol-2-yl-[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]butanoic acid / agonistYM / Pemafibrate ChemComp-ITY: icosa-5,8,11,14-tetraynoic acid ChemComp-T4T: 2-tetradecylsulfanylethanoic acid / agonistYM / Tetradecylthioacetic acid ChemComp-WY1: 2-({4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO]PYRIMIDIN-2-YL}SULFANYL)ACETIC ACID / agonistYM / Pirinixic acid ChemComp-GW9: 2-chloro-5-nitro-N-phenylbenzamide ChemComp-E0O: 2-(4-chloranylphenoxy)-2-methyl-propanoic acid / Clofibric acid ChemComp-F5A: 2-[4-(4-chlorobenzene-1-carbonyl)phenoxy]-2-methylpropanoic acid / medicationYM / Fenofibrate ChemComp-C5F: 2-{4-[(1S)-2,2-dichlorocyclopropyl]phenoxy}-2-methylpropanoic acid ChemComp-STE: STEARIC ACID / Stearic acid ChemComp-OLA: OLEIC ACID / Oleic acid ChemComp-ACD: ARACHIDONIC ACID / Arachidonic acid ChemComp-EPA: 5,8,11,14,17-EICOSAPENTAENOIC ACID / medicationYM / Ethyl eicosapentaenoic acid ChemComp-EWR: (2S)-2-ethoxy-3-[4-[2-[2-methyl-5-(4-methylsulfanylphenyl)pyrrol-1-yl]ethoxy]phenyl]propanoic acid / Saroglitazar ChemComp-PEM*: 2-[P-[2-P-CHLOROBENZAMIDO)ETHYL]PHENOXY]-2-METHYLPROPIONIC ACID / Bezafibrate
Source	homo sapiens (human)
Keywords	TRANSCRIPTION / Nuclear receptor / Protein-ligand complex / PPAR