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Structure paper

TitleThe structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.
Journal, issue, pagesFebs J., Vol. 287, Page 3273-3297, Year 2020
Publish dateApr 21, 2019 (structure data deposition date)
AuthorsChitnumsub, P. / Jaruwat, A. / Talawanich, Y. / Noytanom, K. / Liwnaree, B. / Poen, S. / Yuthavong, Y.
External linksFebs J. / PubMed:31883412
MethodsX-ray diffraction
Resolution2.3 - 2.95 Å
Structure data

PDB-6jwq:
Crystal structure of Plasmodium falciparum HPPK-DHPS wild type
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-6jwr:
Crystal structure of Plasmodium falciparum HPPK-DHPS wild type with Pteroate
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-6jws:
Crystal structure of Plasmodium falciparum HPPK-DHPS A437G with Pteroate
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-6jwt:
Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613T triple mutant with Pteroate
Method: X-RAY DIFFRACTION / Resolution: 2.56 Å

PDB-6jwu:
Crystal structure of Plasmodium falciparum HPPK-DHPS wild type with STZ-DHP
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

PDB-6jwv:
Crystal structure of Plasmodium falciparum HPPK-DHPS A437G with STZ-DHP
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-6jww:
Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613T triple mutant with STZ-DHP
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

PDB-6jwx:
Crystal structure of Plasmodium falciparum HPPK-DHPS wild type with SDX-DHP
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-6jwy:
Crystal structure of Plasmodium falciparum HPPK-DHPS A437G with SDX-DHP
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-6jwz:
Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613S triple mutant with SDX-DHP
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

PDB-6kck:
Crystal structure of Plasmodium falciparum HPPK-DHPS wild type with pterin and p-hydroxybenzoate
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-6kcl:
Crystal structure of Plasmodium falciparum HPPK-DHPS A437G/K540E with pterin and p-hydroxybenzoate
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-6kcm:
Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613S with pterin and p-hydrobenzoate
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-CA:
Unknown entry

ChemComp-ACT:
ACETATE ION

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

ChemComp-HOH:
WATER

ChemComp-PT1:
PTEROIC ACID

ChemComp-PH2:
2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE

ChemComp-XTZ:
4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}-N-(1,3-thiazol-2-yl)benzenesulfonamide

ChemComp-PO4:
PHOSPHATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-CKL:
4-[(2-azanyl-4-oxidanylidene-7,8-dihydro-3~{H}-pteridin-6-yl)methylamino]-~{N}-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-PE0:
PTERINE

ChemComp-PHB:
P-HYDROXYBENZOIC ACID

ChemComp-APC:
DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER / AMP-CPP, energy-carrying molecule analogue*YM

Source
  • plasmodium falciparum (malaria parasite P. falciparum)
KeywordsTRANSFERASE / TIM barrel / kinase

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