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Structure paper

TitleCapped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Journal, issue, pagesNucleic Acids Res., Vol. 46, Page 956-971, Year 2018
Publish dateOct 31, 2017 (structure data deposition date)
AuthorsPflug, A. / Gaudon, S. / Resa-Infante, P. / Lethier, M. / Reich, S. / Schulze, W.M. / Cusack, S.
External linksNucleic Acids Res. / PubMed:29202182
MethodsX-ray diffraction
Resolution1 - 3.9 Å
Structure data

PDB-6euv:
Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindole cap-binding inhibitor (VX-787)
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-6euw:
Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an azaindazole inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.0 Å

PDB-6eux:
Structure of the midlink and cap-binding domains of influenza B polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

PDB-6euy:
Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
Method: X-RAY DIFFRACTION / Resolution: 3.0 Å

PDB-6evj:
Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and capped RNA primer
Method: X-RAY DIFFRACTION / Resolution: 3.9 Å

PDB-6evk:
Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and cap analogue m7GTP
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-21G:
(2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid

ChemComp-NI:
NICKEL (II) ION / Nickel

ChemComp-HOH:
WATER / Water

ChemComp-BYB:
(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid

ChemComp-GOL:
GLYCEROL / Glycerol

ChemComp-SO4:
SULFATE ION / Sulfate

ChemComp-ZN:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION / Phosphate

ChemComp-MGP:
7-METHYL-GUANOSINE-5'-TRIPHOSPHATE

Source
  • influenza a virus (strain a/victoria/3/1975 h3n2)
  • influenza a virus (a/duck/shantou/4610/2003(h5n1))
  • influenza b virus (b/memphis/13/2003)
  • influenza a virus (a/victoria/3/1975(h3n2))
  • influenza a virus (a/little yellow-shouldered bat/guatemala/060/2010(h17n10))
  • synthetic construct (others)
  • influenza a virus
KeywordsRNA BINDING PROTEIN / Influenza A polymerase / PB2 subunit / cap-binding domain / cap-binding inhibitor / influenza RNA-dependent RNA polymerase / inhibitor / Influenza B polymerase PB2 subunit cap-binding domain cap-binding inhibitor / Influenza A polymerase PB2 subunit cap-binding domain cap-binding inhibitor / VIRAL PROTEIN / Influenza virus / RNA-dependent RNA polymerase / capped RNA primer / cap analogue

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