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Structure paper

TitleStructural Basis of Smoothened Activation in Hedgehog Signaling.
Journal, issue, pagesCell, Vol. 174, Page 312-324.e16, Year 2018
Publish dateApr 14, 2018 (structure data deposition date)
AuthorsHuang, P. / Zheng, S. / Wierbowski, B.M. / Kim, Y. / Nedelcu, D. / Aravena, L. / Liu, J. / Kruse, A.C. / Salic, A.
External linksCell / PubMed:29804838
MethodsX-ray diffraction
Resolution3.751 - 3.9 Å
Structure data

PDB-6d32:
Crystal structure of Xenopus Smoothened in complex with cyclopamine
Method: X-RAY DIFFRACTION / Resolution: 3.751 Å

PDB-6d35:
Crystal structure of Xenopus Smoothened in complex with cholesterol
Method: X-RAY DIFFRACTION / Resolution: 3.9 Å

Chemicals

ChemComp-CY8:
Cyclopamine / alkaloid*YM

ChemComp-CLR:
CHOLESTEROL

Source
  • xenopus laevis (African clawed frog)
  • escherichia coli (E. coli)
KeywordsMEMBRANE PROTEIN / GPCR / Hedgehog signaling / Class Frizzled / Sterol

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