タイトル | Structural Insights into Substrate Selectivity and Activity of Bacterial Polyphosphate Kinases |
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ジャーナル・号・ページ | Acs Catalysis, Vol. 8, Page 10746-10760, Year 2018 |
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掲載日 | 2017年8月12日 (構造データの登録日) |
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著者 | Nocek, B. / Khusnutdinova, A.N. / Ruszkowski, M. / Flick, R. / Burda, M. / Batyrova, K. / Brown, G. / Mucha, A. / Joachimiak, A. / Berlicki, L. / Yakunin, A.F. |
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リンク | Acs Catalysis / PubMedで検索 |
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手法 | X線回折 |
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解像度 | 1.805 - 2.65 Å |
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構造データ | PDB-6an9: Crystal structure of PPk2 class III in complex with ADP from Cytophaga hutchinsonii ATCC 33406 手法: X-RAY DIFFRACTION / 解像度: 1.891 Å PDB-6ang: Crystal structure of PPK2 Class III in the complex with AMP from Cytophaga hutchinsonii ATCC 33406 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å PDB-6anh: Crystal structure of PPK2 class III in complex with Guanosine 5-tetraphosphate 手法: X-RAY DIFFRACTION / 解像度: 2.65 Å PDB-6aqe: Crystal structure of PPK2 in complex with Mg ATP 手法: X-RAY DIFFRACTION / 解像度: 1.805 Å PDB-6aqn: Crystal structure of PPK2 in complex with phosphonic acid inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.199 Å PDB-6au0: Crystal structure of PPK2 (Class III) in complex with bisphosphonate inhibitor (2-((3,5-dichlorophenyl)amino)ethane-1,1-diyl)diphosphonic acid 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-6b18: Crystal structure of PPK3 Class III in complex with inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å |
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化合物 | ChemComp-ADP: ADENOSINE-5'-DIPHOSPHATE / ADP / ADP, エネルギー貯蔵分子*YM / アデノシン二リン酸
ChemComp-BKP: 5'-O-[(S)-hydroxy{[(S)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]guanosine / グアノシン5′-四りん酸
ChemComp-ATP: ADENOSINE-5'-TRIPHOSPHATE / ATP / ATP, エネルギー貯蔵分子*YM / アデノシン三リン酸
ChemComp-BOY: [(R)-hydroxy(4-methylphenyl)methyl]phosphonic acid
ChemComp-C8A: {[(4-benzylphenyl)amino]methylene}bis(phosphonic acid)
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由来 | - cytophaga hutchinsonii (strain atcc 33406 / ncimb 9469) (バクテリア)
- deinococcus radiodurans (strain atcc 13939 / dsm 20539 / jcm 16871 / lmg 4051 / nbrc 15346 / ncimb 9279 / r1 / vkm b-1422) (放射線耐性)
- cytophaga hutchinsonii (バクテリア)
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キーワード | TRANSFERASE (転移酵素) / PPK2 / polyphosphate kinase / ADP-binding / AMP / kinase (キナーゼ) / Guanosine 5-tetraphosphate / Mg / ATP (アデノシン三リン酸) / transferase/transferase inhibitor / Inhibitor / (hydroxy(p-toluyl)methyl)phosphonic acid / transferase-transferase inhibitor complex / bisphosphonate inhibitor |
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