タイトル | Molecular basis for the unusual ring reconstruction in fungal meroterpenoid biogenesis |
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ジャーナル・号・ページ | Nat. Chem. Biol., Vol. 13, Page 1066-1073, Year 2017 |
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掲載日 | 2016年11月26日 (構造データの登録日) |
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著者 | Mori, T. / Iwabuchi, T. / Hoshino, S. / Wang, H. / Matsuda, Y. / Abe, I. |
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リンク | Nat. Chem. Biol. / PubMed:28759016 |
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手法 | X線回折 |
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解像度 | 1.798 - 2.3 Å |
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構造データ | PDB-5wqf: Structure of fungal meroterpenoid isomerase Trt14 手法: X-RAY DIFFRACTION / 解像度: 2.001 Å PDB-5wqg: Structure of fungal meroterpenoid isomerase Trt14 complexed with terretonin D 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-5wqh: Structure of fungal meroterpenoid isomerase Trt14 complexed with substrate analog and endo-terretonin D 手法: X-RAY DIFFRACTION / 解像度: 2.102 Å PDB-5wqi: Structure of fungal meroterpenoid isomerase Trt14 complexed with hydrolyzed product 手法: X-RAY DIFFRACTION / 解像度: 1.899 Å PDB-5x9j: Structure of PrhC from Penicillium brasilianum NBRC 6234 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-5x9k: Structure of AusH from Aspergillus nidulans 手法: X-RAY DIFFRACTION / 解像度: 1.798 Å |
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化合物 | ChemComp-7WU: methyl (2S,4aR,4bS,5S,6aS,10aS,10bS,12aS)-2,4b,7,7,10a,12,12a-heptamethyl-5-oxidanyl-1,4,6,8-tetrakis(oxidanylidene)-4a,5,6a,9,10,10b-hexahydronaphtho[1,2-h]isochromene-2-carboxylate
ChemComp-7WX: methyl (5S,7S,8S,9S,10S,13R,14R,16S)-4,4,8,10,12,13,16-heptamethyl-7,16-bis(oxidanyl)-3,6,15,17-tetrakis(oxidanylidene)-2,5,7,9-tetrahydro-1H-cyclopenta[a]phenanthrene-14-carboxylate
ChemComp-7X0: (1R,2S,4aS,4bS,8aS,10S,10aS)-2-[(2S)-3-methoxy-2-methyl-2-oxidanyl-3-oxidanylidene-propanoyl]-2,3,4b,8,8,10a-hexamethyl-10-oxidanyl-7,9-bis(oxidanylidene)-1,4a,5,6,8a,10-hexahydrophenanthrene-1-carboxylic acid
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由来 | - aspergillus terreus nih 2624 (カビ)
- penicillium brasilianum (菌類)
- emericella nidulans fgsc a4 (カビ)
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キーワード | ISOMERASE / meroterpenoid / terretonin / paraherquonin / Austinol |
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