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Structure paper

TitleStructure of Crenezumab Complex with Abeta Shows Loss of beta-Hairpin.
Journal, issue, pagesSci Rep, Vol. 6, Page 39374-, Year 2016
Publish dateMay 29, 2017 (structure data deposition date)
AuthorsUltsch, M. / Li, B. / Maurer, T. / Mathieu, M. / Adolfsson, O. / Muhs, A. / Pfeifer, A. / Pihlgren, M. / Bainbridge, T.W. / Reichelt, M. ...Ultsch, M. / Li, B. / Maurer, T. / Mathieu, M. / Adolfsson, O. / Muhs, A. / Pfeifer, A. / Pihlgren, M. / Bainbridge, T.W. / Reichelt, M. / Ernst, J.A. / Eigenbrot, C. / Fuh, G. / Atwal, J.K. / Watts, R.J. / Wang, W.
External linksSci Rep / PubMed:27996029
MethodsX-ray diffraction
Resolution2.32 - 2.501 Å
Structure data

PDB-5vzx:
Crystal structure of crenezumab Fab
Method: X-RAY DIFFRACTION / Resolution: 2.501 Å

PDB-5vzy:
Crystal structure of crenezumab Fab in complex with Abeta
Method: X-RAY DIFFRACTION / Resolution: 2.32 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / immunoglobulin

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