EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	X-ray structures define human P2X3 receptor gating cycle and antagonist action.
ジャーナル・号・ページ	Nature, Vol. 538, Page 66-71, Year 2016
掲載日	2016年8月6日 (構造データの登録日)
著者	Mansoor, S.E. / Lu, W. / Oosterheert, W. / Shekhar, M. / Tajkhorshid, E. / Gouaux, E.
リンク	Nature / PubMed:27626375
手法	X線回折
解像度	2.773 - 4.025 Å
構造データ	PDB-5svj: Crystal structure of the ATP-gated human P2X3 ion channel in the closed, apo state 手法: X-RAY DIFFRACTION / 解像度: 2.984 Å PDB-5svk: Crystal structure of the ATP-gated human P2X3 ion channel in the ATP-bound, open state 手法: X-RAY DIFFRACTION / 解像度: 2.773 Å PDB-5svl: Crystal structure of the ATP-gated human P2X3 ion channel in the ATP-bound, closed (desensitized) state 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-5svm: Crystal structure of the ATP-gated human P2X3 ion channel bound to agonist 2-methylthio-ATP in the desensitized state 手法: X-RAY DIFFRACTION / 解像度: 3.093 Å PDB-5svp: Anomalous sulfur signal reveals the position of agonist 2-methylthio-ATP bound to the ATP-gated human P2X3 ion channel in the desensitized state 手法: X-RAY DIFFRACTION / 解像度: 3.298 Å PDB-5svq: Crystal structure of the ATP-gated human P2X3 ion channel bound to competitive antagonist TNP-ATP 手法: X-RAY DIFFRACTION / 解像度: 3.25 Å PDB-5svr: Crystal structure of the ATP-gated human P2X3 ion channel bound to competitive antagonist A-317491 手法: X-RAY DIFFRACTION / 解像度: 3.13 Å PDB-5svs: Anomalous Mn2+ signal reveals a divalent cation-binding site in the head domain of the ATP-gated human P2X3 ion channel 手法: X-RAY DIFFRACTION / 解像度: 4.025 Å PDB-5svt: Anomalous Cs+ signal reveals the site of Na+ ion entry to the channel pore of the human P2X3 ion channel through the extracellular fenestrations 手法: X-RAY DIFFRACTION / 解像度: 3.794 Å
化合物	ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose / N-アセチル-β-D-グルコサミン ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-NA: Unknown entry / ナトリウムカチオン ChemComp-PG4: TETRAETHYLENE GLYCOL / テトラエチレングリコ-ル / 沈殿剤YM ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-HOH: WATER ChemComp-ATP: ADENOSINE-5'-TRIPHOSPHATE / ATP / ATP, エネルギー貯蔵分子YM ChemComp-MHA: (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID / ADA / pH緩衝剤YM ChemComp-ACT: ACETATE ION / 酢酸イオン ChemComp-TRS: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / トリス(ヒドロキシメチル)メチルアンモニウム / pH緩衝剤YM ChemComp-6AT: 2-(methylsulfanyl)adenosine 5'-(tetrahydrogen triphosphate) / 2-メチルチオATP ChemComp-128: SPIRO(2,4,6-TRINITROBENZENE[1,2A]-2O',3O'-METHYLENE-ADENINE-TRIPHOSPHATE ChemComp-71C: 5-{[(3-phenoxyphenyl)methyl][(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}benzene-1,2,4-tricarboxylic acid / A-317491
由来	homo sapiens (ヒト)
キーワード	MEMBRANE PROTEIN / Ion Channel / Apo State / Open State / Desensitized State / Anomalous Signal / Antagonist State / Membrane protein Ion Channel Antagonist State / Anomalous Signal Mg ion