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Structure paper

TitleX-ray structures define human P2X3 receptor gating cycle and antagonist action.
Journal, issue, pagesNature, Vol. 538, Page 66-71, Year 2016
Publish dateAug 6, 2016 (structure data deposition date)
AuthorsMansoor, S.E. / Lu, W. / Oosterheert, W. / Shekhar, M. / Tajkhorshid, E. / Gouaux, E.
External linksNature / PubMed:27626375
MethodsX-ray diffraction
Resolution2.773 - 4.025 Å
Structure data

PDB-5svj:
Crystal structure of the ATP-gated human P2X3 ion channel in the closed, apo state
Method: X-RAY DIFFRACTION / Resolution: 2.984 Å

PDB-5svk:
Crystal structure of the ATP-gated human P2X3 ion channel in the ATP-bound, open state
Method: X-RAY DIFFRACTION / Resolution: 2.773 Å

PDB-5svl:
Crystal structure of the ATP-gated human P2X3 ion channel in the ATP-bound, closed (desensitized) state
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-5svm:
Crystal structure of the ATP-gated human P2X3 ion channel bound to agonist 2-methylthio-ATP in the desensitized state
Method: X-RAY DIFFRACTION / Resolution: 3.093 Å

PDB-5svp:
Anomalous sulfur signal reveals the position of agonist 2-methylthio-ATP bound to the ATP-gated human P2X3 ion channel in the desensitized state
Method: X-RAY DIFFRACTION / Resolution: 3.298 Å

PDB-5svq:
Crystal structure of the ATP-gated human P2X3 ion channel bound to competitive antagonist TNP-ATP
Method: X-RAY DIFFRACTION / Resolution: 3.25 Å

PDB-5svr:
Crystal structure of the ATP-gated human P2X3 ion channel bound to competitive antagonist A-317491
Method: X-RAY DIFFRACTION / Resolution: 3.13 Å

PDB-5svs:
Anomalous Mn2+ signal reveals a divalent cation-binding site in the head domain of the ATP-gated human P2X3 ion channel
Method: X-RAY DIFFRACTION / Resolution: 4.025 Å

PDB-5svt:
Anomalous Cs+ signal reveals the site of Na+ ion entry to the channel pore of the human P2X3 ion channel through the extracellular fenestrations
Method: X-RAY DIFFRACTION / Resolution: 3.794 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose / N-Acetylglucosamine

ChemComp-MG:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM / Polyethylene glycol

ChemComp-EDO:
1,2-ETHANEDIOL / Ethylene glycol

ChemComp-HOH:
WATER / Water

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM / Adenosine triphosphate

ChemComp-MHA:
(CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID / pH buffer*YM / ADA (buffer)

ChemComp-ACT:
ACETATE ION / Acetate

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM / Tris

ChemComp-6AT:
2-(methylsulfanyl)adenosine 5'-(tetrahydrogen triphosphate)

ChemComp-128:
SPIRO(2,4,6-TRINITROBENZENE[1,2A]-2O',3O'-METHYLENE-ADENINE-TRIPHOSPHATE

ChemComp-71C:
5-{[(3-phenoxyphenyl)methyl][(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}benzene-1,2,4-tricarboxylic acid

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Ion Channel / Apo State / Open State / Desensitized State / Anomalous Signal / Antagonist State / Membrane protein Ion Channel Antagonist State / Anomalous Signal Mg ion

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