Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
Journal, issue, pages	ACS Chem. Biol., Vol. 12, Page 2906-2914, Year 2017
Publish date	Aug 16, 2017 (structure data deposition date)
Authors	McIntyre, P.J. / Collins, P.M. / Vrzal, L. / Birchall, K. / Arnold, L.H. / Mpamhanga, C. / Coombs, P.J. / Burgess, S.G. / Richards, M.W. / Winter, A. ...McIntyre, P.J. / Collins, P.M. / Vrzal, L. / Birchall, K. / Arnold, L.H. / Mpamhanga, C. / Coombs, P.J. / Burgess, S.G. / Richards, M.W. / Winter, A. / Veverka, V. / Delft, F.V. / Merritt, A. / Bayliss, R.
External links	ACS Chem. Biol. / PubMed:29045126
Methods	X-ray diffraction
Resolution	1.69 - 2.56 Å
Structure data	PDB-5orl: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 1.69 Å PDB-5orn: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 2.19 Å PDB-5oro: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 2.12 Å PDB-5orp: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 2.19 Å PDB-5orr: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 2.09 Å PDB-5ors: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 1.98 Å PDB-5ort: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 2.56 Å PDB-5orv: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 1.88 Å PDB-5orw: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 2 Å PDB-5orx: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 1.88 Å PDB-5ory: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 1.99 Å PDB-5orz: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 1.92 Å PDB-5os0: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 1.74 Å PDB-5os1: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 1.9 Å PDB-5os2: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 1.92 Å PDB-5os3: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 1.81 Å PDB-5os4: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 1.88 Å PDB-5os5: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 1.74 Å PDB-5os6: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 2.2 Å PDB-5osd: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 1.99 Å PDB-5ose: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 1.9 Å PDB-5osf: Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment Method: X-RAY DIFFRACTION / Resolution: 1.89 Å
Chemicals	ChemComp-ADP: ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying moleculeYM ChemComp-MG: Unknown entry ChemComp-CL: Unknown entry ChemComp-A4W: ~{N}-(3-chloranyl-2-fluoranyl-phenyl)-3-sulfanyl-propanamide ChemComp-HOH: WATER ChemComp-A5E: 3-thiophen-2-yl-4,5-dihydro-1~{H}-pyridazin-6-one ChemComp-A5H: 3-(4-chlorophenyl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole ChemComp-A5K: 1-[3-chloranyl-5-(trifluoromethyl)pyridin-2-yl]-1,4-diazepane ChemComp-A5Q: 4-[4-(trifluoromethyl)phenyl]-1,2,3-thiadiazol-5-amine ChemComp-A5W: cyclobutyl-[4-(2-methoxyphenyl)piperidin-1-yl]methanone ChemComp-A5Z: [3-[2,6-bis(chloranyl)phenyl]-5-methyl-1,2-oxazol-4-yl]methanol ChemComp-A65: [3,5-bis(methylsulfanyl)-1,2-thiazol-4-yl]methanol ChemComp-A6E: 3-(4-fluoranylphenoxy)-1-thiomorpholin-4-yl-propan-1-one ChemComp-A6H: 6-[2,6-bis(chloranyl)phenoxy]pyridin-3-amine ChemComp-AY4: 2,4-bis(fluoranyl)-6-(1~{H}-pyrazol-3-yl)phenol ChemComp-A6W: methyl 3-azanyl-5-thiophen-2-yl-thiophene-2-carboxylate ChemComp-A6Z: 2-[4-(3-chlorophenyl)piperazin-1-ium-1-yl]ethanenitrile ChemComp-A7H: 6-ethoxy-2-methyl-1,3-benzothiazole ChemComp-A7K: [2-[4-(hydroxymethyl)piperidin-1-yl]phenyl]methylazanium ChemComp-A7N: (1~{R})-1-(4-ethoxyphenyl)ethanamine ChemComp-A8H: (3~{a}~{R},5~{S},7~{a}~{S})-5-phenyl-3~{a},4,5,6,7,7~{a}-hexahydroisoindole-1,3-dione ChemComp-SO4: SULFATE ION ChemComp-A8K: 4-(4-hydroxyphenyl)sulfanylphenol ChemComp-A7Q: (6-phenoxypyridin-3-yl)methanol ChemComp-A9B: 5-(4-chlorophenyl)furan-2-carbohydrazide ChemComp-A98: methyl ~{N}-(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)carbamate ChemComp-A9E*: 2-(4-ethylphenoxy)-1-piperidin-1-yl-ethanone
Source	homo sapiens (human)
Keywords	TRANSFERASE / kinase / allosteric inhibitor / fragment