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TitleThe cryo-EM Structure of a Novel 40S Kinetoplastid-Specific Ribosomal Protein.
Journal, issue, pagesStructure, Vol. 25, Issue 12, Page 1785-11794.e3, Year 2017
Publish dateDec 5, 2017
AuthorsJailson Brito Querido / Eder Mancera-Martínez / Quentin Vicens / Anthony Bochler / Johana Chicher / Angelita Simonetti / Yaser Hashem /
PubMed AbstractKinetoplastids are potentially lethal protozoan pathogens affecting more than 20 million people worldwide. There is a critical need for more specific targets for the development of safer anti- ...Kinetoplastids are potentially lethal protozoan pathogens affecting more than 20 million people worldwide. There is a critical need for more specific targets for the development of safer anti-kinetoplastid therapeutic molecules that can replace the scarce and highly cytotoxic current drugs. The kinetoplastid ribosome represents a potential therapeutic target due to its relative structural divergence when compared with its human counterpart. However, several kinetoplastid-specific ribosomal features remain uncharacterized. Here, we present the near-atomic cryoelectron microscopy structure of a novel bona fide kinetoplastid-specific ribosomal (r-) protein (KSRP) bound to the ribosome. KSRP is an essential protein located at the solvent face of the 40S subunit, where it binds and stabilizes kinetoplastid-specific domains of rRNA, suggesting its role in ribosome integrity. KSRP also interacts with the r-protein eS6 at a region that is only conserved in kinetoplastids. The kinetoplastid-specific ribosomal environment of KSRP provides a promising target for the design of safer anti-kinetoplastidian drugs.
External linksStructure / PubMed:29107485
MethodsEM (single particle)
Resolution2.9 - 4.4 Å
Structure data

3844

5opt

EMDB-3844: 80S from Trypanosoma cruzi
PDB-5opt: Structure of KSRP in context of Trypanosoma cruzi 40S
Method: EM (single particle) / Resolution: 4.0 Å

EMDB-3845:
40S from Trypanosoma cruzi
Method: EM (single particle) / Resolution: 4.4 Å

PDB-5osg:
Structure of KSRP in context of Leishmania donovani 80S
Method: ELECTRON MICROSCOPY / Resolution: 2.9 Å

Source
  • trypanosoma cruzi (eukaryote)
  • trypanosoma cruzi (strain cl brener) (eukaryote)
  • leishmania donovani (eukaryote)
KeywordsRIBOSOME / Kinetoplastids / cryo-EM / KSRP

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