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Structure paper

TitleUnraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60.
Journal, issue, pagesPlos One, Vol. 15, Page e0242725-e0242725, Year 2020
Publish dateJul 15, 2016 (structure data deposition date)
AuthorsHsiao, H.T. / Crichlow, G.V. / Murphy, J.W. / Folta-Stogniew, E.J. / Lolis, E.J. / Braddock, D.T.
External linksPlos One / PubMed:33253191
MethodsX-ray diffraction
Resolution1.91 - 2.8 Å
Structure data

PDB-5kvy:
CRYSTAL STRUCTURE OF THE TWO TANDEM RRM DOMAINS OF PUF60 BOUND TO A PORTION OF AN ADML PRE-MRNA 3' SPLICE SITE ANALOG
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-5kw1:
Crystal Structure of the Two Tandem RRM Domains of PUF60 Bound to a Modified AdML Pre-mRNA 3' Splice Site Analogue
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-5kw6:
Two Tandem RRM Domains of PUF60 Bound to an AdML Pre-mRNA 3' Splice Site Analogue with a Modified Binding-Site Nucleic Acid Base
Method: X-RAY DIFFRACTION / Resolution: 1.91 Å

PDB-5kwq:
Two Tandem RRM Domains of FBP-Interacting Repressor (FIR), also Known as PUF60
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
  • unidentified adenovirus
KeywordsSPLICING/DNA / TANDEM RRMS / PROTEIN-NUCLEIC ACID COMPLEX / SPLICING FACTOR / SPLICING-DNA complex / SPLICING / c-Myc Regulation

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