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Structure paper

TitleStructural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 113, Page E3403-E3412, Year 2016
Publish dateApr 18, 2016 (structure data deposition date)
AuthorsZhao, B. / Shu, C. / Gao, X. / Sankaran, B. / Du, F. / Shelton, C.L. / Herr, A.B. / Ji, J.Y. / Li, P.
External linksProc. Natl. Acad. Sci. USA / PubMed:27302953
MethodsX-ray diffraction
Resolution1.6 - 2.913 Å
Structure data

PDB-5jej:
Phosphorylated STING in complex with IRF-3 CTD
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-5jek:
Phosphorylated MAVS in complex with IRF-3
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-5jel:
Phosphorylated TRIF in complex with IRF-3
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-5jem:
Complex of IRF-3 with CBP
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-5jeo:
Phosphorylated Rotavirus NSP1 in complex with IRF-3
Method: X-RAY DIFFRACTION / Resolution: 1.719 Å

PDB-5jer:
Structure of Rotavirus NSP1 bound to IRF-3
Method: X-RAY DIFFRACTION / Resolution: 2.913 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

Source
  • homo sapiens (human)
  • rotavirus a
KeywordsIMMUNE SYSTEM / Innate Immunity / Signaling / Viral Immuinity / Viral Immunity

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