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- PDB-5jem: Complex of IRF-3 with CBP -

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Basic information

Entry
Database: PDB / ID: 5jem
TitleComplex of IRF-3 with CBP
Components
  • CREB-binding protein
  • Interferon regulatory factor 3
KeywordsIMMUNE SYSTEM / Innate Immunity / Signaling
Function / homology
Function and homology information


IRF3 mediated activation of type 1 IFN / MDA-5 signaling pathway / macrophage apoptotic process / programmed necrotic cell death / peptide lactyltransferase (CoA-dependent) activity / TRIF-dependent toll-like receptor signaling pathway / NFE2L2 regulating ER-stress associated genes / protein N-acetyltransferase activity / Activation of the TFAP2 (AP-2) family of transcription factors / NFE2L2 regulating inflammation associated genes ...IRF3 mediated activation of type 1 IFN / MDA-5 signaling pathway / macrophage apoptotic process / programmed necrotic cell death / peptide lactyltransferase (CoA-dependent) activity / TRIF-dependent toll-like receptor signaling pathway / NFE2L2 regulating ER-stress associated genes / protein N-acetyltransferase activity / Activation of the TFAP2 (AP-2) family of transcription factors / NFE2L2 regulating inflammation associated genes / N-terminal peptidyl-lysine acetylation / regulation of smoothened signaling pathway / LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production / NFE2L2 regulates pentose phosphate pathway genes / positive regulation of type I interferon-mediated signaling pathway / IRF3-mediated induction of type I IFN / NFE2L2 regulating MDR associated enzymes / positive regulation of cytokine production involved in inflammatory response / MRF binding / RUNX1 regulates transcription of genes involved in differentiation of myeloid cells / cGAS/STING signaling pathway / signal transduction involved in regulation of gene expression / mRNA transcription / Regulation of FOXO transcriptional activity by acetylation / Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells / RUNX3 regulates NOTCH signaling / Nuclear events mediated by NFE2L2 / NOTCH4 Intracellular Domain Regulates Transcription / Regulation of NFE2L2 gene expression / Regulation of gene expression by Hypoxia-inducible Factor / NOTCH3 Intracellular Domain Regulates Transcription / negative regulation of transcription by RNA polymerase I / TRAF6 mediated IRF7 activation / NFE2L2 regulating tumorigenic genes / NFE2L2 regulating anti-oxidant/detoxification enzymes / toll-like receptor 4 signaling pathway / protein-lysine-acetyltransferase activity / type I interferon-mediated signaling pathway / embryonic digit morphogenesis / DNA-binding transcription activator activity / protein acetylation / cytoplasmic pattern recognition receptor signaling pathway / homeostatic process / Notch-HLH transcription pathway / Formation of paraxial mesoderm / cellular response to exogenous dsRNA / positive regulation of transforming growth factor beta receptor signaling pathway / histone acetyltransferase activity / acetyltransferase activity / FOXO-mediated transcription of cell death genes / stimulatory C-type lectin receptor signaling pathway / Zygotic genome activation (ZGA) / TP53 Regulates Transcription of Genes Involved in Cytochrome C Release / positive regulation of interferon-alpha production / histone acetyltransferase complex / immune system process / canonical NF-kappaB signal transduction / positive regulation of type I interferon production / cellular response to nutrient levels / Attenuation phase / positive regulation of double-strand break repair via homologous recombination / histone H4K16 acetyltransferase activity / histone H3K56 acetyltransferase activity / histone H3K23 acetyltransferase activity / histone H2AK5 acetyltransferase activity / histone H2AK9 acetyltransferase activity / histone H2BK5 acetyltransferase activity / histone H2BK12 acetyltransferase activity / histone H3K4 acetyltransferase activity / histone H3K27 acetyltransferase activity / histone H3K36 acetyltransferase activity / histone H3K122 acetyltransferase activity / histone H3K18 acetyltransferase activity / histone H3K9 acetyltransferase activity / histone H3K14 acetyltransferase activity / histone H4K5 acetyltransferase activity / histone H4K8 acetyltransferase activity / histone H4K12 acetyltransferase activity / regulation of cellular response to heat / histone acetyltransferase / : / Regulation of lipid metabolism by PPARalpha / NPAS4 regulates expression of target genes / antiviral innate immune response / Transferases; Acyltransferases; Transferring groups other than aminoacyl groups / Transcriptional and post-translational regulation of MITF-M expression and activity / CD209 (DC-SIGN) signaling / TICAM1-dependent activation of IRF3/IRF7 / BMAL1:CLOCK,NPAS2 activates circadian expression / Regulation of innate immune responses to cytosolic DNA / positive regulation of interferon-beta production / SUMOylation of transcription cofactors / lipopolysaccharide-mediated signaling pathway / Activation of gene expression by SREBF (SREBP) / Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) / Negative regulators of DDX58/IFIH1 signaling / promoter-specific chromatin binding / Formation of the beta-catenin:TCF transactivating complex / Heme signaling / Transcriptional activation of mitochondrial biogenesis
Similarity search - Function
Creb-binding Protein; Chain: A / Nuclear receptor coactivator, CREB-bp-like, interlocking domain / Tumour Suppressor Smad4 - #10 / Interferon regulatory factor-3 / Interferon-regulatory factor 3 / Interferon-regulatory factor 3 / Interferon regulatory factor, conserved site / IRF tryptophan pentad repeat DNA-binding domain signature. / Interferon regulatory factor transcription factor / interferon regulatory factor ...Creb-binding Protein; Chain: A / Nuclear receptor coactivator, CREB-bp-like, interlocking domain / Tumour Suppressor Smad4 - #10 / Interferon regulatory factor-3 / Interferon-regulatory factor 3 / Interferon-regulatory factor 3 / Interferon regulatory factor, conserved site / IRF tryptophan pentad repeat DNA-binding domain signature. / Interferon regulatory factor transcription factor / interferon regulatory factor / Interferon regulatory factor DNA-binding domain / IRF tryptophan pentad repeat DNA-binding domain profile. / SMAD-like domain superfamily / Tumour Suppressor Smad4 / Nuclear receptor coactivator, CREB-bp-like, interlocking / Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily / Creb binding / Zinc finger, TAZ-type / TAZ domain superfamily / TAZ zinc finger / Zinc finger TAZ-type profile. / TAZ zinc finger, present in p300 and CBP / : / Histone acetyltransferase p300-like, PHD domain / Coactivator CBP, KIX domain / CREB-binding protein/p300, atypical RING domain / CBP/p300-type histone acetyltransferase domain / CBP/p300, atypical RING domain superfamily / KIX domain / CREB-binding protein/p300, atypical RING domain / KIX domain profile. / CBP/p300-type histone acetyltransferase (HAT) domain profile. / Histone acetyltransferase Rtt109/CBP / Histone acetylation protein / Histone acetylation protein / Coactivator CBP, KIX domain superfamily / Zinc finger ZZ-type signature. / Zinc-binding domain, present in Dystrophin, CREB-binding protein. / Zinc finger, ZZ type / Zinc finger, ZZ-type / Zinc finger, ZZ-type superfamily / Zinc finger ZZ-type profile. / SMAD/FHA domain superfamily / Nuclear receptor coactivator, interlocking / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Zinc finger, RING/FYVE/PHD-type / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Sandwich / Orthogonal Bundle / Mainly Beta / Mainly Alpha
Similarity search - Domain/homology
Interferon regulatory factor 3 / CREB-binding protein
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / Resolution: 2.5 Å
AuthorsZhao, B. / Li, P.
CitationJournal: Proc.Natl.Acad.Sci.USA / Year: 2016
Title: Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Authors: Zhao, B. / Shu, C. / Gao, X. / Sankaran, B. / Du, F. / Shelton, C.L. / Herr, A.B. / Ji, J.Y. / Li, P.
History
DepositionApr 18, 2016Deposition site: RCSB / Processing site: RCSB
Revision 1.0Jun 15, 2016Provider: repository / Type: Initial release
Revision 1.1Jun 29, 2016Group: Database references
Revision 1.2Mar 6, 2024Group: Data collection / Database references / Derived calculations
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / citation / database_2 / pdbx_struct_oper_list
Item: _citation.journal_id_CSD / _database_2.pdbx_DOI ..._citation.journal_id_CSD / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Interferon regulatory factor 3
C: CREB-binding protein
B: Interferon regulatory factor 3
D: CREB-binding protein
E: Interferon regulatory factor 3
F: CREB-binding protein
G: Interferon regulatory factor 3
H: CREB-binding protein


Theoretical massNumber of molelcules
Total (without water)116,1968
Polymers116,1968
Non-polymers00
Water4,071226
1
A: Interferon regulatory factor 3
C: CREB-binding protein
B: Interferon regulatory factor 3
D: CREB-binding protein


Theoretical massNumber of molelcules
Total (without water)58,0984
Polymers58,0984
Non-polymers00
Water724
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area7740 Å2
ΔGint-41 kcal/mol
Surface area21710 Å2
MethodPISA
2
E: Interferon regulatory factor 3
F: CREB-binding protein
G: Interferon regulatory factor 3
H: CREB-binding protein


Theoretical massNumber of molelcules
Total (without water)58,0984
Polymers58,0984
Non-polymers00
Water724
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area7880 Å2
ΔGint-39 kcal/mol
Surface area21480 Å2
MethodPISA
Unit cell
Length a, b, c (Å)85.230, 88.660, 92.810
Angle α, β, γ (deg.)90.00, 113.09, 90.00
Int Tables number4
Space group name H-MP1211

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Components

#1: Protein
Interferon regulatory factor 3 / IRF-3


Mass: 23774.992 Da / Num. of mol.: 4 / Fragment: UNP residues 189-398
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: IRF3 / Production host: Escherichia coli (E. coli) / References: UniProt: Q14653
#2: Protein/peptide
CREB-binding protein


Mass: 5274.103 Da / Num. of mol.: 4 / Fragment: UNP residues 2065-2111
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: CREBBP, CBP / Production host: Escherichia coli (E. coli) / References: UniProt: Q92793, histone acetyltransferase
#3: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 226 / Source method: isolated from a natural source / Formula: H2O

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.78 Å3/Da / Density % sol: 55.69 %
Crystal growTemperature: 277 K / Method: vapor diffusion, hanging drop / Details: 0.1 M HEPES pH 7.5, 25% PEG 3350

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Data collection

DiffractionMean temperature: 120 K
Diffraction sourceSource: ROTATING ANODE / Type: RIGAKU MICROMAX-007 / Wavelength: 1.542 Å
DetectorType: RIGAKU RAXIS IV++ / Detector: IMAGE PLATE / Date: Oct 25, 2015
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 1.542 Å / Relative weight: 1
ReflectionResolution: 2.5→36.992 Å / Num. obs: 42426 / % possible obs: 96.3 % / Redundancy: 3.5 % / Net I/σ(I): 6.2

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Processing

Software
NameVersionClassification
PHENIX1.9_1692refinement
MOSFLMdata reduction
Aimlessdata scaling
PHASERphasing
RefinementResolution: 2.5→36.992 Å / SU ML: 0.42 / Cross valid method: FREE R-VALUE / σ(F): 1.33 / Phase error: 27.41
RfactorNum. reflection% reflection
Rfree0.242 1985 4.68 %
Rwork0.192 --
obs0.1943 42378 96.05 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å
Refinement stepCycle: LAST / Resolution: 2.5→36.992 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms7650 0 0 226 7876
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.0037849
X-RAY DIFFRACTIONf_angle_d0.62410687
X-RAY DIFFRACTIONf_dihedral_angle_d14.5152871
X-RAY DIFFRACTIONf_chiral_restr0.0231159
X-RAY DIFFRACTIONf_plane_restr0.0031392
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
2.5-2.56250.37821180.33082579X-RAY DIFFRACTION86
2.5625-2.63180.38341310.30942568X-RAY DIFFRACTION87
2.6318-2.70920.36281260.28142677X-RAY DIFFRACTION89
2.7092-2.79660.29341390.26372775X-RAY DIFFRACTION92
2.7966-2.89660.2821460.2632842X-RAY DIFFRACTION96
2.8966-3.01250.30591380.26442878X-RAY DIFFRACTION97
3.0125-3.14950.31841630.24182938X-RAY DIFFRACTION98
3.1495-3.31550.24711320.20573015X-RAY DIFFRACTION100
3.3155-3.5230.23091440.19132985X-RAY DIFFRACTION100
3.523-3.79480.26931580.17612997X-RAY DIFFRACTION100
3.7948-4.17620.19191520.16293002X-RAY DIFFRACTION100
4.1762-4.77940.20451360.14983023X-RAY DIFFRACTION100
4.7794-6.01740.20961530.15993030X-RAY DIFFRACTION100
6.0174-36.99560.19821490.16523084X-RAY DIFFRACTION100
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
17.0881-0.2782-2.47877.64080.40824.62570.1045-0.56840.82210.37340.0436-0.1338-0.68870.0983-0.1240.3902-0.0342-0.10860.32430.00590.3834-25.1657-7.19255.5507
25.9772-0.4130.50613.1861-0.47432.1739-0.08340.23550.0887-0.25420.0472-0.0335-0.1018-0.00110.03290.4060.00210.00170.25260.02510.3881-20.9538-7.8176-3.9329
35.60350.04110.48961.5258-0.12690.4081-0.06960.7524-0.6033-0.19270.05160.1149-0.0347-0.18190.03890.3386-0.0043-0.04270.3417-0.04690.4512-32.4327-16.9479-6.1792
46.6753-2.6943-1.38454.62851.74445.152-0.14220.72680.235-0.5050.2537-0.19070.11040.1249-0.04460.4559-0.1047-0.04730.6203-0.06010.5255-35.7107-40.5548-11.8113
57.5532-6.2263.75225.1671-3.25523.0615-0.8555-1.2729-1.91671.04841.81841.27570.178-0.7562-0.93890.6578-0.09190.0120.77420.09641.0803-51.0803-20.178710.8352
68.8883-1.81471.55132.1129-2.9444.47220.5295-0.3762-2.36270.07640.4548-0.95391.3146-0.7719-0.91650.66790.0609-0.07690.67960.11990.8434-39.6759-22.961710.6778
73.32071.66424.79842.62791.21037.9387-0.1759-0.61410.17530.1150.42130.2699-0.0705-0.5895-0.15830.42520.05890.02740.43130.04690.4826-44.3207-11.7398.131
87.0515-2.5519-5.45232.09811.83874.3382-0.491-0.4377-0.9031-0.2939-0.90360.43320.326-1.1471.13690.36930.0527-0.05810.8037-0.06290.6435-53.6279-21.0074-0.677
93.89331.28671.68292.8377-0.37294.3572-0.1008-0.33640.1170.25770.1086-0.24990.5198-0.0334-0.02390.40040.01170.10730.3198-0.05360.4569-15.5755-41.22863.8303
105.8319-4.8659-0.76114.7292.47086.4365-0.1073-1.9439-1.72262.83630.33342.28851.50340.4237-0.31721.6537-0.1451-0.13370.75820.09371.471-23.1877-54.71096.0826
112.4462-2.43420.22653.3234-0.72665.2474-0.2877-0.2884-0.04570.19620.29810.6199-0.0533-0.25330.06090.3172-0.05750.00390.4164-0.05770.6024-32.563-40.75131.1774
123.6511-3.18530.17994.5290.88664.2021-0.00060.2999-0.3559-0.08180.1171-0.130.47190.22-0.14380.4679-0.0240.03250.2931-0.03520.5364-15.1137-47.5554-6.7446
138.83765.38834.21026.11755.43767.3093-0.38120.64410.3429-1.65510.15450.4755-0.51090.21410.30650.53930.09130.12220.61080.02920.4943-16.3156-40.3286-11.6903
145.78153.36921.39575.73371.20582.2481-0.30151.14950.7034-0.63850.3389-0.0773-0.24280.2320.01140.3958-0.00630.12250.40480.08640.558-0.9624-33.6581-8.7134
153.2496-1.9101-0.32736.69461.74290.50850.53741.13940.4636-1.2591-0.5491-0.0897-0.05630.06320.02680.3743-0.05910.07710.47530.06860.4657-24.0417-35.5498-10.7489
160.19170.355-0.4622.03770.05652.62350.0327-0.15661.0973-0.253-0.2108-0.22370.15690.36250.19940.2722-0.00730.06560.2736-00.5798-6.5139-32.16940.3035
178.1922-2.32162.92654.9223-0.85923.06790.22610.5165-0.8711-0.7627-0.20820.4899-0.15850.421-0.07030.4169-0.04610.1850.51390.13810.6323-7.2786-10.0032-11.1376
185.616-0.7711-5.62011.69060.9615.6162-0.1512-2.02432.3886-0.36320.2580.0972-0.51350.4118-0.33750.57660.05510.01480.4824-0.11520.94853.2803-30.431410.0587
197.21772.7608-2.13385.6869-3.52827.5582-0.0120.09331.26110.3037-0.0547-0.4979-0.25440.70680.07230.32630.03090.03550.4402-0.01540.70536.3382-34.71952.5509
206.0599-0.74220.53478.39512.83936.98490.26630.324-0.1706-0.6081-0.0225-0.87260.0560.8815-0.21550.5466-0.0160.01580.61750.07210.3668-4.1645-35.780323.5481
212.9768-0.70010.37768.5825-0.57572.68960.0291-0.4807-0.01210.3155-0.0066-0.8733-0.01460.49570.07330.5860.0117-0.08160.6696-0.01220.4369-3.9553-31.963832.9006
223.49431.04660.8174.7076-0.88362.55640.0905-0.6554-0.07970.3758-0.1040.24930.2954-0.0440.03570.61220.0399-0.02280.52640.06640.2932-16.3659-40.037534.552
238.2781-0.4939-1.11795.94231.81615.5360.62-1.17290.91810.37160.33120.125-0.3831-0.844-0.77820.8343-0.02460.21190.80070.19690.6282-39.8823-35.860939.9489
244.31991.5683-2.18054.6037-5.15955.7751-0.02870.7041-0.8241-0.3292-0.031.13641.2513-1.4754-0.09791.0593-0.2057-0.04070.9362-0.06011.0008-24.8294-50.44117.0394
257.70114.2084-5.92399.7898-6.43428.18550.05950.1246-0.47540.07670.170.19341.4158-0.468-0.11291.0568-0.093-0.10370.4084-0.01940.4504-20.7171-55.684924.1999
266.1805-1.1307-1.25863.6222-3.65336.62750.45550.61120.1054-0.6232-0.04690.909-0.4271-1.0721-0.340.65170.1059-0.06620.6484-0.00550.4134-37.7043-18.335424.3328
272.6612-0.54720.87033.4097-0.61682.0042-0.0568-0.50880.03040.28220.14950.7776-0.1815-0.6427-0.12430.57440.0860.04850.6040.03120.4418-39.6869-23.475831.3127
284.1519-1.2626-2.84485.873-0.11214.2505-0.2515-1.94570.90621.16120.51290.0742-0.61930.3692-0.19930.9010.16970.10390.7244-0.04230.3919-33.6264-17.359640.2084
292.21010.90450.60193.76621.41441.4332-0.0893-0.50180.00760.51090.0505-0.1957-0.5164-0.120.04460.80290.1048-0.04010.563-0.03740.3039-25.7493-13.875635.4882
305.7577-0.63592.50414.4218-1.54263.01930.2705-0.9484-0.45340.42090.0297-0.121-0.2170.4731-0.40290.9609-0.0935-0.2610.7763-0.15870.6654-1.8804-18.2540.2316
313.73710.148-3.18452.29-1.40283.54431.15120.46790.0432-1.7444-0.6524-0.25242.0251-0.6241-0.59611.69870.006-0.31361.2573-0.01290.9271-17.38234.061119.3729
323.89672.36716.24084.94064.19532.01210.19980.86840.0709-1.25030.0303-1.389-1.87741.4924-0.49061.2531-0.1289-0.00260.9561-0.12090.7983-18.0808-6.98818.2576
337.45114.5514.47827.24835.30574.1913-0.5738-0.36620.78920.27530.49550.8255-2.32290.2850.12081.24880.10370.06560.4535-0.01950.443-27.8601-0.241222.0979
346.2158-1.58742.97845.9783-2.35765.6682-0.870.02181.35920.40910.1962-0.6005-1.22790.73540.43641.6348-0.1387-0.02980.5633-0.10170.8661-15.43565.059430.2984
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection details
1X-RAY DIFFRACTION1chain 'A' and (resid 196 through 240 )
2X-RAY DIFFRACTION2chain 'A' and (resid 241 through 316 )
3X-RAY DIFFRACTION3chain 'A' and (resid 317 through 382 )
4X-RAY DIFFRACTION4chain 'A' and (resid 383 through 398 )
5X-RAY DIFFRACTION5chain 'C' and (resid 2065 through 2072 )
6X-RAY DIFFRACTION6chain 'C' and (resid 2073 through 2079 )
7X-RAY DIFFRACTION7chain 'C' and (resid 2080 through 2092 )
8X-RAY DIFFRACTION8chain 'C' and (resid 2093 through 2106 )
9X-RAY DIFFRACTION9chain 'B' and (resid 196 through 229 )
10X-RAY DIFFRACTION10chain 'B' and (resid 230 through 240 )
11X-RAY DIFFRACTION11chain 'B' and (resid 241 through 268 )
12X-RAY DIFFRACTION12chain 'B' and (resid 269 through 296 )
13X-RAY DIFFRACTION13chain 'B' and (resid 297 through 316 )
14X-RAY DIFFRACTION14chain 'B' and (resid 317 through 342 )
15X-RAY DIFFRACTION15chain 'B' and (resid 343 through 363 )
16X-RAY DIFFRACTION16chain 'B' and (resid 364 through 382 )
17X-RAY DIFFRACTION17chain 'B' and (resid 383 through 398 )
18X-RAY DIFFRACTION18chain 'D' and (resid 2065 through 2079 )
19X-RAY DIFFRACTION19chain 'D' and (resid 2080 through 2106 )
20X-RAY DIFFRACTION20chain 'E' and (resid 196 through 240 )
21X-RAY DIFFRACTION21chain 'E' and (resid 241 through 316 )
22X-RAY DIFFRACTION22chain 'E' and (resid 317 through 382 )
23X-RAY DIFFRACTION23chain 'E' and (resid 383 through 398 )
24X-RAY DIFFRACTION24chain 'F' and (resid 2065 through 2079 )
25X-RAY DIFFRACTION25chain 'F' and (resid 2080 through 2106 )
26X-RAY DIFFRACTION26chain 'G' and (resid 199 through 240 )
27X-RAY DIFFRACTION27chain 'G' and (resid 241 through 296 )
28X-RAY DIFFRACTION28chain 'G' and (resid 297 through 316 )
29X-RAY DIFFRACTION29chain 'G' and (resid 317 through 382 )
30X-RAY DIFFRACTION30chain 'G' and (resid 383 through 398 )
31X-RAY DIFFRACTION31chain 'H' and (resid 2065 through 2071 )
32X-RAY DIFFRACTION32chain 'H' and (resid 2072 through 2079 )
33X-RAY DIFFRACTION33chain 'H' and (resid 2080 through 2092 )
34X-RAY DIFFRACTION34chain 'H' and (resid 2093 through 2106 )

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