タイトル | Computationally Designed Bispecific Antibodies using Negative State Repertoires. |
---|
ジャーナル・号・ページ | Structure, Vol. 24, Page 641-651, Year 2016 |
---|
掲載日 | 2015年8月31日 (構造データの登録日) |
---|
著者 | Leaver-Fay, A. / Froning, K.J. / Atwell, S. / Aldaz, H. / Pustilnik, A. / Lu, F. / Huang, F. / Yuan, R. / Hassanali, S. / Chamberlain, A.K. ...Leaver-Fay, A. / Froning, K.J. / Atwell, S. / Aldaz, H. / Pustilnik, A. / Lu, F. / Huang, F. / Yuan, R. / Hassanali, S. / Chamberlain, A.K. / Fitchett, J.R. / Demarest, S.J. / Kuhlman, B. |
---|
リンク | Structure / PubMed:26996964 |
---|
手法 | X線回折 |
---|
解像度 | 1.9 - 2.95 Å |
---|
構造データ | PDB-5di8: Fc Knob-Hole Heterodimer T366W + T366S/L368A/Y407V 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-5dj0: Fc Heterodimer Design 11.2 Y349S/K370Y + E357D/S364Q 手法: X-RAY DIFFRACTION / 解像度: 2.28 Å PDB-5dj2: Fc Heterodimer Design 7.4 Y407A + T366V/K409V 手法: X-RAY DIFFRACTION / 解像度: 2.56 Å PDB-5dj6: Fc Heterodimer Design 6.1 F405W/Y407A + T366M 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-5dj8: Fc Heterodimer Design 7.7 D399M/Y407A + T366V/K409I 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-5dja: Fc Heterodimer Design 9.1 Y407M + T366I 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-5djc: Fc Heterodimer Design 8.1 L368V/Y407A + T366V/K409F 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-5djd: Fc Heterodimer Design 5.1 T366V + Y407F 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-5djx: Fc Heterodimer Design 2.9 L368M/K370E + E357A/S364G 手法: X-RAY DIFFRACTION / 解像度: 2.25 Å PDB-5djy: Fc Heterodimer Design 20.8 Y349S/T366V/K370Y/K409V + E357D/S364Q/Y407A 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-5djz: Fc Heterodimer Design 7.8 D399M/Y407A + T366V/K409V 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-5dk0: Fc Heterodimer Design 20.8.34 Y349S/T366M/K370Y/K409V + E356G/E357D/S364Q/Y407A 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-5dk2: Fc Heterodimer E356K/D399K + K392D/K409D 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-5dvk: Fc Design 7.7 B chain homodimer T366V/K409I 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-5dvl: Fc Design 20.8.37 A chain homodimer Y349S/T366M/K370Y/K409V 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-5dvm: Fc Design 20.8.37 B chain homodimer E357D/S364R/Y407A 手法: X-RAY DIFFRACTION / 解像度: 2.95 Å PDB-5dvn: Fc K392D/K409D homodimer 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-5dvo: Fc K392D/K409D homodimer 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å |
---|
化合物 | |
---|
由来 | - homo sapiens (ヒト)
- synthetic construct (人工物)
|
---|
キーワード | IMMUNE SYSTEM (免疫系) / Heterodimer / Immunoglobulin (抗体) / CH3 / Fc / Bispecific Antibody (二重特異性モノクローナル抗体) / head-to-tail homodimer / IgG1_Fc - NONE |
---|