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TitleComputationally Designed Bispecific Antibodies using Negative State Repertoires.
Journal, issue, pagesStructure, Vol. 24, Page 641-651, Year 2016
Publish dateAug 31, 2015 (structure data deposition date)
AuthorsLeaver-Fay, A. / Froning, K.J. / Atwell, S. / Aldaz, H. / Pustilnik, A. / Lu, F. / Huang, F. / Yuan, R. / Hassanali, S. / Chamberlain, A.K. ...Leaver-Fay, A. / Froning, K.J. / Atwell, S. / Aldaz, H. / Pustilnik, A. / Lu, F. / Huang, F. / Yuan, R. / Hassanali, S. / Chamberlain, A.K. / Fitchett, J.R. / Demarest, S.J. / Kuhlman, B.
External linksStructure / PubMed:26996964
MethodsX-ray diffraction
Resolution1.9 - 2.95 Å
Structure data

PDB-5di8:
Fc Knob-Hole Heterodimer T366W + T366S/L368A/Y407V
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-5dj0:
Fc Heterodimer Design 11.2 Y349S/K370Y + E357D/S364Q
Method: X-RAY DIFFRACTION / Resolution: 2.28 Å

PDB-5dj2:
Fc Heterodimer Design 7.4 Y407A + T366V/K409V
Method: X-RAY DIFFRACTION / Resolution: 2.56 Å

PDB-5dj6:
Fc Heterodimer Design 6.1 F405W/Y407A + T366M
Method: X-RAY DIFFRACTION / Resolution: 2.0 Å

PDB-5dj8:
Fc Heterodimer Design 7.7 D399M/Y407A + T366V/K409I
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-5dja:
Fc Heterodimer Design 9.1 Y407M + T366I
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-5djc:
Fc Heterodimer Design 8.1 L368V/Y407A + T366V/K409F
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-5djd:
Fc Heterodimer Design 5.1 T366V + Y407F
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-5djx:
Fc Heterodimer Design 2.9 L368M/K370E + E357A/S364G
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-5djy:
Fc Heterodimer Design 20.8 Y349S/T366V/K370Y/K409V + E357D/S364Q/Y407A
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-5djz:
Fc Heterodimer Design 7.8 D399M/Y407A + T366V/K409V
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-5dk0:
Fc Heterodimer Design 20.8.34 Y349S/T366M/K370Y/K409V + E356G/E357D/S364Q/Y407A
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-5dk2:
Fc Heterodimer E356K/D399K + K392D/K409D
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-5dvk:
Fc Design 7.7 B chain homodimer T366V/K409I
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-5dvl:
Fc Design 20.8.37 A chain homodimer Y349S/T366M/K370Y/K409V
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-5dvm:
Fc Design 20.8.37 B chain homodimer E357D/S364R/Y407A
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

PDB-5dvn:
Fc K392D/K409D homodimer
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-5dvo:
Fc K392D/K409D homodimer
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-HOH:
WATER / Water

ChemComp-IOD:
IODIDE ION / Iodide

ChemComp-SO4:
SULFATE ION / Sulfate

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / Heterodimer / Immunoglobulin / CH3 / Fc / Bispecific Antibody / head-to-tail homodimer / IgG1_Fc - NONE

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