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Structure paper

TitleStructural basis for inhibition of TLR2 by staphylococcal superantigen-like protein 3 (SSL3).
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 112, Page 11018-11023, Year 2015
Publish dateAug 6, 2015 (structure data deposition date)
AuthorsKoymans, K.J. / Feitsma, L.J. / Brondijk, T.H. / Aerts, P.C. / Lukkien, E. / Lossl, P. / van Kessel, K.P. / de Haas, C.J. / van Strijp, J.A. / Huizinga, E.G.
External linksProc. Natl. Acad. Sci. USA / PubMed:26283364
MethodsX-ray diffraction
Resolution1.94 - 3.2 Å
Structure data

PDB-5d3d:
Crystal structure of Staphylococcal Superantigen-Like protein 3
Method: X-RAY DIFFRACTION / Resolution: 1.94 Å

PDB-5d3i:
Crystal structure of the SSL3-TLR2 complex
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-SCN:
THIOCYANATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-PCW:
1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE / DOPC, phospholipid*YM

Source
  • staphylococcus aureus (strain nctc 8325) (bacteria)
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / Superantigens / Superantigen-like proteins / SSL / SSL3 / Toll-Like Receptor 2 / TLR2 / Immunology / Inflammation / Inhibition / TLR6 / Lipopeptide / phosphatidylcholine / PC / immune evasion / innate immunity

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