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Structure paper

TitleStructures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 107, Page 17152-17157, Year 2010
Publish dateAug 5, 2010 (structure data deposition date)
AuthorsDunkle, J.A. / Xiong, L. / Mankin, A.S. / Cate, J.H.
External linksProc. Natl. Acad. Sci. USA / PubMed:20876128
MethodsX-ray diffraction
Resolution3.1 - 3.2891 Å
Structure data

PDB-4v7s:
Crystal structure of the E. coli ribosome bound to telithromycin.
Method: X-RAY DIFFRACTION / Resolution: 3.2547 Å

PDB-4v7t:
Crystal structure of the E. coli ribosome bound to chloramphenicol.
Method: X-RAY DIFFRACTION / Resolution: 3.1942 Å

PDB-4v7u:
Crystal structure of the E. coli ribosome bound to erythromycin.
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-4v7v:
Crystal structure of the E. coli ribosome bound to clindamycin.
Method: X-RAY DIFFRACTION / Resolution: 3.2891 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-TEL:
TELITHROMYCIN / antibiotic*YM

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CLM:
CHLORAMPHENICOL / antibiotic*YM

ChemComp-ERY:
ERYTHROMYCIN A / antibiotic*YM

ChemComp-CLY:
CLINDAMYCIN / medication, antibiotic*YM

Source
  • escherichia coli (E. coli)
KeywordsRIBOSOME/ANTIBIOTIC / Protein biosynthesis / ribosomes / RNA / tRNA / transfer / telithromycin / ketolide / macrolide / antibiotic / exit / peptidyl / 30S / 70S / 16S / ribosomal subunit / small / RIBOSOME / RIBOSOME-ANTIBIOTIC complex / erythromycin / clindamycin

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