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Structure paper

TitleStructural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection.
Journal, issue, pagesJ. Virol., Vol. 88, Page 12895-12906, Year 2014
Publish dateSep 24, 2012 (structure data deposition date)
AuthorsAcharya, P. / Tolbert, W.D. / Gohain, N. / Wu, X. / Yu, L. / Liu, T. / Huang, W. / Huang, C.C. / Kwon, Y.D. / Louder, R.K. ...Acharya, P. / Tolbert, W.D. / Gohain, N. / Wu, X. / Yu, L. / Liu, T. / Huang, W. / Huang, C.C. / Kwon, Y.D. / Louder, R.K. / Luongo, T.S. / McLellan, J.S. / Pancera, M. / Yang, Y. / Zhang, B. / Flinko, R. / Foulke, J.S. / Sajadi, M.M. / Kamin-Lewis, R. / Robinson, J.E. / Martin, L. / Kwong, P.D. / Guan, Y. / DeVico, A.L. / Lewis, G.K. / Pazgier, M.
External linksJ. Virol. / PubMed:25165110
MethodsX-ray diffraction
Resolution1.85 - 4.28 Å
Structure data

PDB-4h8w:
Crystal structure of non-neutralizing and ADCC-potent antibody N5-i5 in complex with HIV-1 clade A/E gp120 and sCD4.
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-4r4b:
Crystal structure of the anti-hiv-1 antibody 2.2c
Method: X-RAY DIFFRACTION / Resolution: 2.199 Å

PDB-4r4f:
Crystal structure of non-neutralizing, A32-like antibody 2.2c in complex with HIV-1 YU2 gp120
Method: X-RAY DIFFRACTION / Resolution: 3.514 Å

PDB-4r4h:
Crystal structure of non-neutralizing, A32-like antibody 2.2c in complex with HIV-1 Env gp120
Method: X-RAY DIFFRACTION / Resolution: 4.28 Å

PDB-4r4n:
Crystal structure of the anti-hiv-1 antibody 2.2c in complex with hiv-1 93ug037 gp120
Method: X-RAY DIFFRACTION / Resolution: 3.56 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-MRD:
(4R)-2-METHYLPENTANE-2,4-DIOL / precipitant*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-BU3:
(R,R)-2,3-BUTANEDIOL

Source
  • homo sapiens (human)
  • human immunodeficiency virus 1
  • synthetic construct (others)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / HIV-1 GP120 / CLADE A/E 93TH057 / VIRAL PROTEIN / VIRAL PROTEIN-IMMUNE SYSTEM complex / IMMUNE SYSTEM / IGG / FAB / HIV / IMMUNOGLOBULIN DOMAIN / VIRAL PROTEIN/IMMUNE SYSTEM/INHIBITOR / HIV-1 attachment protein / Membrane / VIRAL PROTEIN-IMMUNE SYSTEM-INHIBITOR complex / HIV-1 attachment glycoprotein gp120 / HIV-1 attachment glycoprotein

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