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Structure paper

TitleStructural basis of microtubule stabilization by laulimalide and peloruside a.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 53, Page 1621-1625, Year 2014
Publish dateDec 18, 2013 (structure data deposition date)
AuthorsProta, A.E. / Bargsten, K. / Northcote, P.T. / Marsh, M. / Altmann, K.H. / Miller, J.H. / Diaz, J.F. / Steinmetz, M.O.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:24470331
MethodsX-ray diffraction
Resolution2.1 - 2.4 Å
Structure data

PDB-4o4h:
Tubulin-Laulimalide complex
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-4o4i:
Tubulin-Laulimalide-Epothilone A complex
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-4o4j:
Tubulin-Peloruside A complex
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-4o4l:
Tubulin-Peloruside A-Epothilone A complex
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-LLM:
Laulimalide

ChemComp-GOL:
GLYCEROL

ChemComp-ACP:
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / AMP-PCP, energy-carrying molecule analogue*YM

ChemComp-HOH:
WATER

ChemComp-EP:
EPOTHILONE A

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-POU:
Peloruside A

Source
  • rattus norvegicus (Norway rat)
  • gallus gallus (chicken)
  • bos taurus (cattle)
KeywordsCELL CYCLE/INHIBITOR / ALPHA-TUBULIN / BETA-TUBULIN / LIGASE / GTPASE / MICROTUBULE / STATHMIN / LAULIMALIDE / CELL CYCLE / TUBULIN FOLD / CYTOSKELETON / CELL CYCLE-INHIBITOR complex / EPOTHILONE A / PELORUSIDE A

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