タイトル | Inhibiting an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa Protects CFTR. |
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ジャーナル・号・ページ | Angew. Chem. Int. Ed. Engl., Vol. 54, Page 9881-9885, Year 2015 |
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掲載日 | 2012年2月6日 (構造データの登録日) |
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著者 | Bahl, C.D. / Hvorecny, K.L. / Bomberger, J.M. / Stanton, B.A. / Hammock, B.D. / Morisseau, C. / Madden, D.R. |
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リンク | Angew. Chem. Int. Ed. Engl. / PubMed:26136396 |
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手法 | X線回折 |
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解像度 | 1.36 - 2.12 Å |
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構造データ | PDB-4dln: Crystal structure of the CFTR inhibitory factor Cif with the D129S mutation 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-4dm7: Crystal structure of the CFTR inhibitory factor Cif with the E153D mutation 手法: X-RAY DIFFRACTION / 解像度: 1.36 Å PDB-4dmf: Crystal structure of the CFTR inhibitory factor Cif with the H177A mutation 手法: X-RAY DIFFRACTION / 解像度: 2.12 Å PDB-4dmh: Crystal structure of the CFTR inhibitory factor Cif with the H207A mutation 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-4dmk: Crystal structure of the CFTR inhibitory factor Cif with the Y239F mutation 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-4yx9: Crystal structure of the CFTR inhibitory factor Cif bound to tiratricol 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å |
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化合物 | |
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由来 |  pseudomonas aeruginosa (緑膿菌) pseudomonas aeruginosa (strain ucbpp-pa14) (緑膿菌)
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キーワード | HYDROLASE / Alpha Beta Hydrolase / Epoxide Hydrolase / secreted / Hydrolase/Hydrolase inhibitor / inhibitor / enzyme / Cif / CFTR / Hydrolase-Hydrolase inhibitor complex |
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