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-Structure paper
Title | Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2. |
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Journal, issue, pages | J. Biol. Chem., Vol. 287, Page 20290-20300, Year 2012 |
Publish date | Sep 20, 2011 (structure data deposition date) |
![]() | Heja, D. / Harmat, V. / Fodor, K. / Wilmanns, M. / Dobo, J. / Kekesi, K.A. / Zavodszky, P. / Gal, P. / Pal, G. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.28 - 3.2 Å |
Structure data | ![]() PDB-3tvj: ![]() PDB-4djz: |
Chemicals | ![]() ChemComp-SO4: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / in vitro evolution / specific inhibitor / allostery / HYDROLASE/HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR complex |