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-Structure paper
Title | Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases. |
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Journal, issue, pages | Biochem. Biophys. Res. Commun., Vol. 445, Page 451-456, Year 2014 |
Publish date | Dec 6, 2013 (structure data deposition date) |
Authors | Schreuder, H.A. / Liesum, A. / Kroll, K. / Bohnisch, B. / Buning, C. / Ruf, S. / Sadowski, T. |
External links | Biochem. Biophys. Res. Commun. / PubMed:24530914 |
Methods | X-ray diffraction |
Resolution | 1.58 - 1.98 Å |
Structure data | PDB-4ci9: PDB-4cia: PDB-4cib: |
Chemicals | ChemComp-DMS: ChemComp-ACT: ChemComp-GOL: ChemComp-SO4: ChemComp-HOH: ChemComp-6KZ: ChemComp-CD: ChemComp-NAG: ChemComp-7UZ: |
Source |
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Keywords | HYDROLASE / DRUG DISCOVERY / SERINE CARBOXYPEPTIDASE / CARDIOVASCULAR DRUG / HEART FAILURE / ENDOTHELIN / TETRAHEDRAL INTERMEDIATE / COVALENT INHIBITOR |