+Search query
-Structure paper
Title | Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 42, Page 536-540, Year 1999 |
Publish date | Dec 19, 1997 (structure data deposition date) |
![]() | Todd, A.K. / Adams, A. / Thorpe, J.H. / Denny, W.A. / Wakelin, L.P. / Cardin, C.J. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.2 - 1.6 Å |
Structure data | ![]() PDB-366d: ![]() PDB-367d: ![]() PDB-452d: |
Chemicals | ![]() ChemComp-DA6: ![]() ChemComp-HOH: ![]() ChemComp-DA5: ![]() ChemComp-BR: ![]() ChemComp-9AD: ![]() ChemComp-MPD: |
![]() | DNA / DRUG INTERCALATION / MAJOR GROOVE BINDING / DOUBLE HELIX / COMPLEXED WITH DRUG / MODIFIED / INTERCALATION / GROOVE BINDING |