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TitleMechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 108, Page 5831-5836, Year 2011
Publish dateJan 18, 2011 (structure data deposition date)
AuthorsBalana, B. / Maslennikov, I. / Kwiatkowski, W. / Stern, K.M. / Bahima, L. / Choe, S. / Slesinger, P.A.
External linksProc. Natl. Acad. Sci. USA / PubMed:21422294
MethodsX-ray diffraction
Resolution1.68 - 3.31 Å
Structure data

PDB-3qdo:
Crystal Structure of PDZ domain of sorting nexin 27 (SNX27) fused to the Gly-Gly linker followed by C-terminal (ESESKV) of GIRK3
Method: X-RAY DIFFRACTION / Resolution: 1.88 Å

PDB-3qe1:
Crystal Structure of PDZ domain of sorting nexin 27 (SNX27) fused to the C-terminal residues (ESESKV) of GIRK3
Method: X-RAY DIFFRACTION / Resolution: 1.68 Å

PDB-3qgl:
Crystal Structure of PDZ domain of sorting nexin 27 (SNX27) in complex with the ESESKV peptide corresponding to the C-terminal tail of GIRK3
Method: X-RAY DIFFRACTION / Resolution: 3.31 Å

Chemicals

ChemComp-HOH:
WATER / Water

Source
  • rattus norvegicus (Norway rat)
KeywordsPROTEIN BINDING / PDZ domain / PDZ binding / GIRK3 regulation / early endosomes / brain / neurons

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