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Structure paper

TitleCrystal structure and putative substrate identification for the Entamoeba histolytica low molecular weight tyrosine phosphatase.
Journal, issue, pagesMol. Biochem. Parasitol., Vol. 193, Page 33-44, Year 2014
Publish dateJul 21, 2009 (structure data deposition date)
AuthorsLinford, A.S. / Jiang, N.M. / Edwards, T.E. / Sherman, N.E. / Van Voorhis, W.C. / Stewart, L.J. / Myler, P.J. / Staker, B.L. / Petri, W.A.
External linksMol. Biochem. Parasitol. / PubMed:24548880
MethodsX-ray diffraction
Resolution1.8 - 2.2 Å
Structure data

PDB-3ido:
Crystal structure of protein tyrosine phosphatase from Entamoeba histolytica with a phosphotyrosine crude mimic HEPES molecule in the active site
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-3ily:
Apo crystal structure of protein tyrosine phosphatase from Entamoeba histolytica featuring a disordered active site
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-3js5:
Crystal structure of protein tyrosine phosphatase from Entamoeba histolytica with Hepes in the active site. High resolution, alternative crystal form with 1 molecule in asymmetric unit
Method: X-RAY DIFFRACTION / Resolution: 1.94 Å

PDB-3jvi:
Product state mimic crystal structure of protein tyrosine phosphatase from Entamoeba histolytica
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

ChemComp-NA:
Unknown entry

ChemComp-SO4:
SULFATE ION

Source
  • entamoeba histolytica hm-1:imss (eukaryote)
  • entamoeba histolytica (eukaryote)
KeywordsHYDROLASE / NIAID / SSGCID / Seattle Structural Genomics Center for Infectious Disease / parasitic protozoan / dysentery / phosphotyrosine / phosphatase / liver abscess

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