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Structure paper

TitleStructural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.
Journal, issue, pagesScience, Vol. 326, Page 1123-1127, Year 2009
Publish dateMay 18, 2009 (structure data deposition date)
AuthorsChen, L. / Do Kwon, Y. / Zhou, T. / Wu, X. / O'Dell, S. / Cavacini, L. / Hessell, A.J. / Pancera, M. / Tang, M. / Xu, L. ...Chen, L. / Do Kwon, Y. / Zhou, T. / Wu, X. / O'Dell, S. / Cavacini, L. / Hessell, A.J. / Pancera, M. / Tang, M. / Xu, L. / Yang, Z.Y. / Zhang, M.Y. / Arthos, J. / Burton, D.R. / Dimitrov, D.S. / Nabel, G.J. / Posner, M.R. / Sodroski, J. / Wyatt, R. / Mascola, J.R. / Kwong, P.D.
External linksScience / PubMed:19965434
MethodsX-ray diffraction
Resolution2.5 - 3.2 Å
Structure data

PDB-3hi1:
Structure of HIV-1 gp120 (core with V3) in Complex with CD4-Binding-Site Antibody F105
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-3idx:
Crystal structure of HIV-gp120 core in complex with CD4-binding site antibody b13, space group C222
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-3idy:
Crystal structure of HIV-gp120 core in complex with CD4-binding site antibody b13, space group C2221
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

Source
  • human immunodeficiency virus type 1
  • homo sapiens (human)
  • human immunodeficiency virus 1
KeywordsSTRUCTURAL PROTEIN/Immune System / HIV / GP120 / CD4 BINDING SITE ANTIBODY / F105 / IMMUNE EVASION / AIDS / Apoptosis / Cell membrane / Cleavage on pair of basic residues / Disulfide bond / Envelope protein / Fusion protein / Glycoprotein / Host-virus interaction / Lipoprotein / Membrane / Palmitate / Transmembrane / Viral immunoevasion / Virion / STRUCTURAL PROTEIN-Immune System COMPLEX / IMMUNE SYSTEM / HIV-1 / antibody / b13 / Envelope glycan protein / CD4-binding site

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