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TitleThe crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket
Journal, issue, pagesJ. Virol., Vol. 83, Page 6534-6545, Year 2009
Publish dateMar 23, 2009 (structure data deposition date)
AuthorsMalet, H. / Coutard, B. / Jamal, S. / Dutartre, H. / Papageorgiou, N. / Neuvonen, M. / Ahola, T. / Forrester, N. / Gould, E.A. / Lafitte, D. ...Malet, H. / Coutard, B. / Jamal, S. / Dutartre, H. / Papageorgiou, N. / Neuvonen, M. / Ahola, T. / Forrester, N. / Gould, E.A. / Lafitte, D. / Ferron, F. / Lescar, J. / Gorbalenya, A.E. / de Lamballerie, X. / Canard, B.
External linksJ. Virol. / PubMed:19386706
MethodsX-ray diffraction
Resolution1.65 - 2.6 Å
Structure data

PDB-3gpg:
Crystal structure of macro domain of Chikungunya virus
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-3gpo:
Crystal structure of macro domain of Chikungunya virus in complex with ADP-ribose
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-3gpq:
Crystal structure of macro domain of Chikungunya virus in complex with RNA
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-3gqe:
Crystal structure of macro domain of Venezuelan Equine Encephalitis virus
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-3gqo:
Crystal structure of macro domain of Venezuelan Equine Encephalitis virus in complex with ADP-ribose
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-APR:
ADENOSINE-5-DIPHOSPHORIBOSE

ChemComp-BCN:
BICINE / pH buffer*YM

Source
  • chikungunya virus
  • venezuelan equine encephalitis virus
KeywordsVIRAL PROTEIN / macro domain / X domain / Chikungunya / alphavirus / virus / VIZIER. Viral enzymes involved in replication / ATP-binding / Cell membrane / Endosome / Helicase / Hydrolase / Lipoprotein / Lysosome / Membrane / Methyltransferase / mRNA capping / mRNA processing / Multifunctional enzyme / Nucleotide-binding / Nucleotidyltransferase / Nucleus / Palmitate / Phosphoprotein / Protease / RNA replication / RNA-binding / RNA-directed RNA polymerase / Thiol protease / Transferase / ADP-ribose / VIRAL PROTEIN/RNA / RNA / VIRAL PROTEIN-RNA complex / Venezuelan Equine Encephalitis virus / Cell projection / VIZIER / Viral enzymes involved in replication

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