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-Structure paper
Title | Efalizumab binding to the LFA-1 alphaL I domain blocks ICAM-1 binding via steric hindrance. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 106, Page 4349-4354, Year 2009 |
Publish date | Sep 26, 2008 (structure data deposition date) |
Authors | Li, S. / Wang, H. / Peng, B. / Zhang, M. / Zhang, D. / Hou, S. / Guo, Y. / Ding, J. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:19258452 |
Methods | X-ray diffraction |
Resolution | 1.8 - 3.6 Å |
Structure data | PDB-3eo9: PDB-3eoa: PDB-3eob: |
Chemicals | ChemComp-HOH: ChemComp-ZN: |
Source |
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Keywords | IMMUNE SYSTEM / Efalizumab / Fab / antibody / IMMUNE SYSTEM/CELL ADHESION / LFA-1 / CD11a / I domain / Alternative splicing / Calcium / Glycoprotein / Integrin / Magnesium / Membrane / Polymorphism / Receptor / Transmembrane / IMMUNE SYSTEM-CELL ADHESION COMPLEX / Cell adhesion |