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TitleMolecular architecture of the "stressosome," a signal integration and transduction hub.
Journal, issue, pagesScience, Vol. 322, Issue 5898, Page 92-96, Year 2008
Publish dateOct 3, 2008
AuthorsJon Marles-Wright / Tim Grant / Olivier Delumeau / Gijs van Duinen / Susan J Firbank / Peter J Lewis / James W Murray / Joseph A Newman / Maureen B Quin / Paul R Race / Alexis Rohou / Willem Tichelaar / Marin van Heel / Richard J Lewis /
PubMed AbstractA commonly used strategy by microorganisms to survive multiple stresses involves a signal transduction cascade that increases the expression of stress-responsive genes. Stress signals can be ...A commonly used strategy by microorganisms to survive multiple stresses involves a signal transduction cascade that increases the expression of stress-responsive genes. Stress signals can be integrated by a multiprotein signaling hub that responds to various signals to effect a single outcome. We obtained a medium-resolution cryo-electron microscopy reconstruction of the 1.8-megadalton "stressosome" from Bacillus subtilis. Fitting known crystal structures of components into this reconstruction gave a pseudoatomic structure, which had a virus capsid-like core with sensory extensions. We suggest that the different sensory extensions respond to different signals, whereas the conserved domains in the core integrate the varied signals. The architecture of the stressosome provides the potential for cooperativity, suggesting that the response could be tuned dependent on the magnitude of chemophysical insult.
External linksScience / PubMed:18832644
MethodsEM (single particle) / X-ray diffraction
Resolution2.3 - 8.3 Å
Structure data

EMDB-1552:
Molecular Architecture of the 'stressosome', a signal transduction hub
Method: EM (single particle) / Resolution: 6.5 Å

EMDB-1555:
Molecular Architecture of the 'stressosome', a signal transduction hub
Method: EM (single particle) / Resolution: 8.0 Å

EMDB-1556:
Molecular Architecture of the 'stressosome', a signal transduction hub
Method: EM (single particle) / Resolution: 8.3 Å

EMDB-1558:
Molecular Architecture of the 'stressosome', a signal transduction hub
Method: EM (single particle) / Resolution: 7.1 Å

PDB-2vy9:
Molecular architecture of the stressosome, a signal integration and transduction hub
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • Bacillus subtilis (bacteria)
  • moorella thermoacetica (bacteria)
KeywordsGENE REGULATION / MOORELLA THERMOACETICA / RSBS / STRESSOSOME / STAS DOMAIN / BACILLUS SUBTILIS

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