+検索条件
-Structure paper
タイトル | Molecular architecture of the "stressosome," a signal integration and transduction hub. |
---|---|
ジャーナル・号・ページ | Science, Vol. 322, Issue 5898, Page 92-96, Year 2008 |
掲載日 | 2008年10月3日 |
著者 | Jon Marles-Wright / Tim Grant / Olivier Delumeau / Gijs van Duinen / Susan J Firbank / Peter J Lewis / James W Murray / Joseph A Newman / Maureen B Quin / Paul R Race / Alexis Rohou / Willem Tichelaar / Marin van Heel / Richard J Lewis / |
PubMed 要旨 | A commonly used strategy by microorganisms to survive multiple stresses involves a signal transduction cascade that increases the expression of stress-responsive genes. Stress signals can be ...A commonly used strategy by microorganisms to survive multiple stresses involves a signal transduction cascade that increases the expression of stress-responsive genes. Stress signals can be integrated by a multiprotein signaling hub that responds to various signals to effect a single outcome. We obtained a medium-resolution cryo-electron microscopy reconstruction of the 1.8-megadalton "stressosome" from Bacillus subtilis. Fitting known crystal structures of components into this reconstruction gave a pseudoatomic structure, which had a virus capsid-like core with sensory extensions. We suggest that the different sensory extensions respond to different signals, whereas the conserved domains in the core integrate the varied signals. The architecture of the stressosome provides the potential for cooperativity, suggesting that the response could be tuned dependent on the magnitude of chemophysical insult. |
リンク | Science / PubMed:18832644 |
手法 | EM (単粒子) / X線回折 |
解像度 | 2.3 - 8.3 Å |
構造データ | EMDB-1552: EMDB-1555: EMDB-1556: EMDB-1558: PDB-2vy9: |
化合物 | ChemComp-HOH: |
由来 |
|
キーワード | GENE REGULATION / MOORELLA THERMOACETICA / RSBS / STRESSOSOME / STAS DOMAIN / BACILLUS SUBTILIS |