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Structure paper

TitleStructural basis for the autoinhibition of c-Abl tyrosine kinase
Journal, issue, pagesCell(Cambridge,Mass. ), Vol. 112, Page 859-871, Year 2003
Publish dateMar 6, 2003 (structure data deposition date)
AuthorsNagar, B. / Hantschel, O. / Young, M.A. / Scheffzek, K. / Veach, D. / Bornmann, W. / Clarkson, B. / Superti-Furga, G. / Kuriyan, J.
External linksCell(Cambridge,Mass. ) / PubMed:12654251
MethodsX-ray diffraction
Resolution1.75 - 3.42 Å
Structure data

PDB-1opj:
Structural basis for the auto-inhibition of c-Abl tyrosine kinase
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-1opk:
Structural basis for the auto-inhibition of c-Abl tyrosine kinase
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-1opl:
Structural basis for the auto-inhibition of c-Abl tyrosine kinase
Method: X-RAY DIFFRACTION / Resolution: 3.42 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-MYR:
MYRISTIC ACID

ChemComp-STI:
4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE / medication, inhibitor*YM

ChemComp-HOH:
WATER

ChemComp-P16:
6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE

ChemComp-GOL:
GLYCEROL

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsTRANSFERASE

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