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Structure paper

TitleCrystal structure of Vat(D): an acetyltransferase that inactivates streptogramin group A antibiotics.
Journal, issue, pagesBiochemistry, Vol. 41, Page 2209-2216, Year 2002
Publish dateNov 30, 2001 (structure data deposition date)
AuthorsSugantino, M. / Roderick, S.L.
External linksBiochemistry / PubMed:11841212
MethodsX-ray diffraction
Resolution2.5 - 2.8 Å
Structure data

PDB-1khr:
Crystal Structure of Vat(D) in Complex with Virginiamycin and Coenzyme A
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-1kk4:
Crystal Structure of Vat(D) in Complex with Acetyl-CoA
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-1kk5:
Crystal Structure of Vat(D) (Form II)
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-1kk6:
Crystal Structure of Vat(D) (Form I)
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-VIR:
VIRGINIAMYCIN M1 / antibiotic*YM

ChemComp-COA:
COENZYME A

ChemComp-HOH:
WATER

ChemComp-ACO:
ACETYL COENZYME *A

Source
  • enterococcus faecium (bacteria)
Keywordstransferase/antibiotic / Antibiotic resistance / Acyltransferase / transferase-antibiotic complex / TRANSFERASE

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