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Structure paper

TitleFlavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site.
Journal, issue, pagesJ. Biol. Chem., Vol. 275, Page 34566-34573, Year 2000
Publish dateMay 11, 2000 (structure data deposition date)
AuthorsOikonomakos, N.G. / Schnier, J.B. / Zographos, S.E. / Skamnaki, V.T. / Tsitsanou, K.E. / Johnson, L.N.
External linksJ. Biol. Chem. / PubMed:10924512
MethodsX-ray diffraction
Resolution1.76 - 2.3 Å
Structure data

PDB-1c8k:
FLAVOPIRIDOL INHIBITS GLYCOGEN PHOSPHORYLASE BY BINDING AT THE INHIBITOR SITE
Method: X-RAY DIFFRACTION / Resolution: 1.76 Å

PDB-1e1y:
Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site
Method: X-RAY DIFFRACTION / Resolution: 2.23 Å

PDB-1gfz:
FLAVOPIRIDOL INHIBITS GLYCOGEN PHOSPHORYLASE BY BINDING AT THE INHIBITOR SITE
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-PLP:
PYRIDOXAL-5'-PHOSPHATE

ChemComp-CPB:
2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE / inhibitor, alkaloid*YM

ChemComp-HOH:
WATER

ChemComp-PO3:
PHOSPHITE ION

ChemComp-GLC:
alpha-D-glucopyranose

ChemComp-IMP:
INOSINIC ACID

ChemComp-CFF:
CAFFEINE / medication*YM

Source
  • oryctolagus cuniculus (rabbit)
KeywordsTRANSFERASE / GLYCOGEN METABOLISM / GLYCOGEN PHOSPHORYLASE B / INHIBITION / INHIBITOR BINDING SITE / ANTITUMOUR AGENT / ALLOSTERIC INHIBITION / GLYCOGEN PHOSPHORYLASE / DIABETES / FLAVOPIRIDOL / INHIBITOR SITE

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