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Title | Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones. |
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Journal, issue, pages | J. Med. Chem., Vol. 41, Page 2461-2480, Year 1998 |
Publish date | Nov 9, 1998 (structure data deposition date) |
![]() | Cregge, R.J. / Durham, S.L. / Farr, R.A. / Gallion, S.L. / Hare, C.M. / Hoffman, R.V. / Janusz, M.J. / Kim, H.O. / Koehl, J.R. / Mehdi, S. ...Cregge, R.J. / Durham, S.L. / Farr, R.A. / Gallion, S.L. / Hare, C.M. / Hoffman, R.V. / Janusz, M.J. / Kim, H.O. / Koehl, J.R. / Mehdi, S. / Metz, W.A. / Peet, N.P. / Pelton, J.T. / Schreuder, H.A. / Sunder, S. / Tardif, C. |
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Methods | X-ray diffraction |
Resolution | 1.8 - 3 Å |
Structure data | ![]() PDB-1b0e: ![]() PDB-1b0f: |
Chemicals | ![]() ChemComp-CA: ![]() ChemComp-SEI: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / SERINE PROTEASE / FLUOROETHYL KETONES |