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TitleTMPRSS2-mediated coronavirus spike activation and inhibition
Journal, issue, pagesTo Be Published
Publish dateFeb 24, 2026 (structure data deposition date)
AuthorsMcCallum M / Case JB / Brown J / Diamond M / Veesler D
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.7 Å
Structure data

75697

11hn

EMDB-75697, PDB-11hn:
SARS-CoV-2 spike S2 trimer stabilized in the early fusion intermediate conformation bound to C77G12 (S2 local refinement)
Method: EM (single particle) / Resolution: 2.7 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • Homo sapiens (human)
  • severe acute respiratory syndrome coronavirus 2
  • saccharomyces cerevisiae s288c (yeast)
KeywordsVIRAL PROTEIN / S2prime / coronavirus / SARS-CoV-2 / spike / fusion / entry / antiviral / Structural Genomics / Seattle Structural Genomics Center for Infectious Disease / SSGCID / VIRAL PROTEIN-HYDROLASE complex / C77G12

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