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TitleAsymmetric architecture and adaptation of Treponema flagella.
Journal, issue, pagesNat Commun, Vol. 17, Issue 1, Year 2026
Publish dateJun 19, 2026
AuthorsJiaqi Wang / Kurni Kurniyati / Wangbiao Guo / Jack M Botting / Hui Wu / Charles V Sindelar / Chunhao Li / Jun Liu /
PubMed AbstractSpirochetes exhibit a distinctive corkscrew-like motility driven by periplasmic flagella that wrap around the cell body in a supercoiled configuration, yet the structural basis of this propulsion ...Spirochetes exhibit a distinctive corkscrew-like motility driven by periplasmic flagella that wrap around the cell body in a supercoiled configuration, yet the structural basis of this propulsion remains poorly understood. Here we combine cryo-electron microscopy, cryo-electron tomography, and genetic and biochemical analyses to determine the assembly and adaptation principles of the supercoiled flagellar filament in Treponema denticola, a major periodontal pathogen. Near-atomic structures reveal a glycosylated FlaB flagellin core encased by an asymmetric sheath. The major sheath protein FlaA forms the bulk of the sheath and mechanically couples to the core through defined interfaces required for efficient motility, whereas four minor sheath proteins (FlaA1, FlaA2, FlaAP1, and FlaAP2) assemble along the concave side of the filament to accommodate intrinsic curvature. Disruption of this asymmetric core-sheath organization compromises force transmission and impairs motility, establishing coordinated asymmetric assembly as a fundamental mechanism underlying spirochetal motility.
External linksNat Commun / PubMed:42321199 / PubMed Central
MethodsEM (single particle)
Resolution3.44 - 3.72 Å
Structure data

75374

10pl

EMDB-75374, PDB-10pl:
Asymmetric architecture and adaptation of Treponema flagella
Method: EM (single particle) / Resolution: 3.44 Å

75375

10pm

EMDB-75375, PDB-10pm:
Asymmetric architecture and adaptation of Treponema flagella
Method: EM (single particle) / Resolution: 3.67 Å

75376

10pp

EMDB-75376, PDB-10pp:
Asymmetric architecture and adaptation of Treponema flagella
Method: EM (single particle) / Resolution: 3.72 Å

Source
  • treponema denticola atcc 35405 (bacteria)
KeywordsMOTOR PROTEIN / Treponema / Flagellin / Motility / Supercoil

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