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TitleHigh-Yield Production of Modified DNA Enables Structural Analysis of PARP2 Recognition of Nucleosomal Single-Strand Breaks
Journal, issue, pagesTo Be Published
Publish dateJan 12, 2026 (structure data deposition date)
AuthorsJayathilake C / Mewhinney CE / Virk RK / Gregory-Lott ER / Nair R / Yang J / Cho E / Day AG / Taylor DJ / Kim TH
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.28 - 4.64 Å
Structure data

EMDB-75074: Nucleosome with an SSB at SHL -2.8 in complex with the WGR domain of human PARP2, Class 1, Consensus map
Method: EM (single particle) / Resolution: 3.3 Å

EMDB-75075: Nucleosome with an SSB at SHL -2.8 in complex with the WGR domain of human PARP2, Class 1, Focused
Method: EM (single particle) / Resolution: 4.64 Å

EMDB-75079: Nucleosome with an SSB at SHL -2.8 in complex with the WGR domain of human PARP2, Class 2, Consensus map
Method: EM (single particle) / Resolution: 3.28 Å

EMDB-75080: Nucleosome with an SSB at SHL -2.8 in complex with the WGR domain of human PARP2, Class 2, Focused map
Method: EM (single particle) / Resolution: 4.09 Å

Source
  • Drosophila melanogaster (fruit fly)

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