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TitleMechanisms of Actin Filament Depolymerization by Cyclase Associated Protein-1 and Cofilin-2
Journal, issue, pagesTo Be Published
Publish dateAug 24, 2025 (structure data deposition date)
AuthorsPalmer NJ / Boczkowska M / Rebowski G / Dominguze R
External linksSearch PubMed
MethodsEM (single particle) / EM (helical sym.)
Resolution2.06 - 3.68 Å
Structure data

EMDB-72305, PDB-9q7k:
Pointed end of Cofilin-2 Bound F-actin
Method: EM (single particle) / Resolution: 3.13 Å

EMDB-72306: Barbed End of Cofilin-2 F-actin, B0 and B-1 Unoccupied
PDB-9q7l: Barbed end of F-actin and cofilin on sides
Method: EM (single particle) / Resolution: 3.68 Å

EMDB-72307: Barbed End of Cofilin-2 F-actin, B-1 Occupied
PDB-9q7m: Barbed end of cofilin actin, cofilin on second-to-last barbed end subunit
Method: EM (single particle) / Resolution: 3.5 Å

EMDB-72308: Barbed End of Cofilin-2 F-actin, Terminal Actins Occupied with Cofilin
PDB-9q7n: Cofilin barbed end, cofilin on the two barbed end subunits
Method: EM (single particle) / Resolution: 3.48 Å

EMDB-72313, PDB-9q7o:
One CAP-1 Bound to the Pointed End of F-actin
Method: EM (single particle) / Resolution: 3.02 Å

EMDB-72330, PDB-9xye:
Two CAP-1 Bound to the Pointed End of F-actin
Method: EM (single particle) / Resolution: 3.18 Å

EMDB-72506, PDB-9y52:
One CAP-1 Bound to the Pointed End of Cofilin F-actin
Method: EM (single particle) / Resolution: 3.46 Å

EMDB-72703, PDB-9y9j:
Two CAP-1 Bound to the Pointed End of Cofilin F-actin
Method: EM (single particle) / Resolution: 3.58 Å

EMDB-72707, PDB-9y9l:
CP at the barbed end with one cofilin on second-to-last subunit
Method: EM (single particle) / Resolution: 3.06 Å

EMDB-72711, PDB-9y9m:
Capping protein bound to the barbed end of cofilactin
Method: EM (single particle) / Resolution: 3.06 Å

EMDB-72712, PDB-9y9p:
Cofilactin filament
Method: EM (helical sym.) / Resolution: 2.06 Å

EMDB-72998, PDB-9yim:
Capping protein bound to the barbed end of F-actin
Method: EM (single particle) / Resolution: 2.62 Å

Chemicals

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • oryctolagus cuniculus (rabbit)
KeywordsPROTEIN FIBRIL / Cytoskeleton / Actin / Filament / Helical

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