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TitleA mu-opioid receptor superagonist analgesic with minimal adverse effects
Journal, issue, pagesNature, Year 2026
Publish dateApr 5, 2025 (structure data deposition date)
AuthorsGomez JL / Ventriglia EN / Frangos ZJ / Sulima A / Robertson MJ / Sacco M / Budinich R / Giosan I / Solis O / Tischer AE ...Gomez JL / Ventriglia EN / Frangos ZJ / Sulima A / Robertson MJ / Sacco M / Budinich R / Giosan I / Solis O / Tischer AE / Bossert JM / Caldwell KE / Bonbrest H / Essmann A / Garcon-Poca MZ / Choi S / Noya MR / Glatfelter G / Robinson M / Mullarkey AA / Brademan DR / Enten G / Dunne W / Schoenborn I / Paule J / Rais R / Holt DP / Dannals RF / Tanda G / Newman AH / Shi L / Huttenhain R / Ferre S / Kiyatkin E / Bonaventura J / Shaham Y / Zachariou V / Baumann MH / Skiniotis G / Rice KC / Michaelides M
External linksNature / Search PubMed
MethodsEM (single particle)
Resolution2.3 Å
Structure data

70071

9o36

EMDB-70071, PDB-9o36:
CryoEM structure of mu-opioid receptor - Gi protein complex bound to fluornitrazene (FNZ)
Method: EM (single particle) / Resolution: 2.3 Å

Chemicals

PDB-1b79:
N-TERMINAL DOMAIN OF DNA REPLICATION PROTEIN DNAB

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsMEMBRANE PROTEIN / Complex / Receptor / Agonist / MOR

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