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-Structure paper
| Title | Structural insights into Sld3-Sld7-dependent Cdc45 loading during replication initiation |
|---|---|
| Journal, issue, pages | Nat Commun, Year 2026 |
| Publish date | Dec 1, 2025 (structure data deposition date) |
Authors | Noguchi Y / Saleh A / Schneider S / Ivanova ME / Chen ZA / Ranjha L / Aramayo R / Tognetti S / Faull SV / Rappsilber J / Speck C |
External links | Nat Commun / Search PubMed |
| Methods | EM (single particle) |
| Resolution | 2.9 - 18.0 Å |
| Structure data | EMDB-55897, PDB-9tgd: EMDB-55904: Cryo-EM structure of MCM2-7 DH bound to Sld3-Sld7 (composite map) EMDB-55918: Cryo-EM structure of MCM2-7 DH bound to Sld3-Sld7, Cdc45 and DNA (composite map) ![]() EMDB-55972: Cryo-EM map of MCM2-7 DH bound to Sld3-Sld7 (consensus map, 882k particles) ![]() EMDB-55973: Cryo-EM map of MCM2-7 DH bound to Sld3-Sld7 (focused map: C2 DH core) ![]() EMDB-55974: Cryo-EM map of MCM2-7 DH bound to Sld3-Sld7 (focused map: Sld3 MRD1:Mcm6) ![]() EMDB-55975: Cryo-EM map of MCM2-7 DH bound to Sld3-Sld7 (focused map: Sld3 MRD2:Mcm4) ![]() EMDB-55976: Cryo-EM map of MCM2-7 DH bound to Sld3-Sld7 (focused map: Sld7:Mcm6) ![]() EMDB-55980: Cryo-EM map of MCM2-7 DH bound to Sld3-Sld7 (DH core C-lobe twist states consensus map, 511k particles) ![]() EMDB-55981: Cryo-EM map of MCM2-7 DH bound to Sld3-Sld7 (DH core C-lobe twist state I) ![]() EMDB-55982: Cryo-EM map of MCM2-7 DH bound to Sld3-Sld7 (DH core C-lobe twist state II) ![]() EMDB-55983: Cryo-EM map of MCM2-7 DH bound to Sld3-Sld7 (DH core C-lobe twist state III) ![]() EMDB-55985: Cryo-EM map of MCM2-7 DH bound to Sld3-Sld7, Cdc45 and DNA (consensus map, 107k particles) ![]() EMDB-55986: Cryo-EM map of MCM2-7 DH bound to Sld3-Sld7, Cdc45 and DNA (focused map: C2 DH core) ![]() EMDB-55987: Cryo-EM map of MCM2-7 DH bound to Sld3-Sld7, Cdc45 and DNA (focused map: Sld3 MRD1/2:Mcm4/6) ![]() EMDB-55988: Cryo-EM map of MCM2-7 DH bound to Sld3-Sld7, Cdc45 and DNA (focused map: Sld7:Mcm6) ![]() EMDB-55989: Cryo-EM map of MCM2-7 DH bound to Sld3-Sld7, Cdc45 and DNA (focused map: Sld3 STD/Cdc45:Mcm2/5) ![]() EMDB-55990: 3DFlex map of MCM2-7 DH-Sld3/7-Cdc45 ![]() EMDB-56009: Cryo-EM map of MCM2-7 DH bound to DNA and two copies of Sld3-Sld7 and Cdc45 (C1 symmetry) ![]() EMDB-56010: Cryo-EM map of MCM2-7 DH bound to DNA and two copies of Sld3-Sld7 and Cdc45 (C2 symmetry) ![]() EMDB-56011: Negative stain-EM map of crosslinked gradient purified Sld3-Sld7 ![]() EMDB-56012: Negative stain-EM map of crosslinked gradient purified Sld3-Sld7-Cdc45 |
| Chemicals | ![]() ChemComp-ATP: ![]() ChemComp-MG: ![]() ChemComp-ZN: ![]() ChemComp-ADP: |
| Source |
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Keywords | REPLICATION / Helicase / Activation / Phosphorylation |
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