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Structure paper

TitleActivation of RyR1 in native membranes
Journal, issue, pagesTo Be Published
Publish dateJul 17, 2025 (structure data deposition date)
AuthorsMikirtumov V / Golusik S / Sprink T / Balyschew N / Yang W / Kotecha A / Kudryashev M
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.6 - 5.12 Å
Structure data

EMDB-54431: Focused map of the N-Terminal cytosolic shell part, Apo-state RyR1 in the native membrane solved by "SPA"
Method: EM (single particle) / Resolution: 3.73 Å

EMDB-54433: Focused map of the BSol cytosolic shell part, Apo-state RyR1 in the native membrane solved by "SPA"
Method: EM (single particle) / Resolution: 4.69 Å

EMDB-54435: Focused map of the CSol activation core part, Apo-state RyR1 in the native membrane solved by "SPA"
Method: EM (single particle) / Resolution: 3.93 Å

EMDB-54437: Focused map of the TMD/TaF/CTD part, Apo-state RyR1 in the native membrane solved by "SPA"
Method: EM (single particle) / Resolution: 3.65 Å

EMDB-54438: Consensus map, Apo-state RyR1 in the native membrane solved by "SPA"
Method: EM (single particle) / Resolution: 3.71 Å

54445

9s16

EMDB-54445, PDB-9s16:
Apo-state RyR1 in the native membrane solved by "SPA
Method: EM (single particle) / Resolution: 3.6 Å

EMDB-54449: Consensus map, Apo-state RyR1 with ACP in the native membrane
Method: EM (single particle) / Resolution: 4.01 Å

EMDB-54450: Focused map of the N-Terminal cytosolic shell part, Apo-state RyR1 with ACP in the native membrane
Method: EM (single particle) / Resolution: 3.88 Å

EMDB-54451: Focused map of the BSol cytosolic shell part, Apo-state RyR1 with ACP in the native membrane
Method: EM (single particle) / Resolution: 5.12 Å

EMDB-54452: Focused map of the CSol activation core part, Apo-state RyR1 with ACP in the native membrane
Method: EM (single particle) / Resolution: 4.18 Å

EMDB-54453: Focused map of the TMD/TaF/CTD part, Apo-state RyR1 with ACP in the native membrane
Method: EM (single particle) / Resolution: 4.09 Å

54454

9s1h

EMDB-54454, PDB-9s1h:
Apo-state RyR1 with ACP in the native membrane
Method: EM (single particle) / Resolution: 4.0 Å

Chemicals

ChemComp-POV:
(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate / phospholipid*YM

ChemComp-ZN:
Unknown entry

ChemComp-ACP:
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / AMP-PCP, energy-carrying molecule analogue*YM

Source
  • oryctolagus cuniculus (rabbit)
KeywordsMEMBRANE PROTEIN / ryanodine receptor type 1 / ryr1 / skeletal muscle / sarcoplasmic reticulum / SR / native membrane

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