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TitleAntagonistic insulin mimetics lock the insulin receptor in an alternative apo-state
Journal, issue, pagesTo Be Published
Publish dateJun 13, 2025 (structure data deposition date)
AuthorsPolak M / Pinkas M / Hernandez MSG / Fabre B / Lubos M / Zakova L / Grzybek M / Schaefer IB / Coskun U / Jiracek J / Novacek J
External linksSearch PubMed
MethodsEM (single particle)
Resolution6.0 - 8.0 Å
Structure data

54015

9rkd

EMDB-54015, PDB-9rkd:
Insulin receptor ectodomain in apo-conformation
Method: EM (single particle) / Resolution: 6.0 Å

54023

9rkw

EMDB-54023, PDB-9rkw:
Insulin receptor ectodomain in complex with s661 insulin mimetic
Method: EM (single particle) / Resolution: 8.0 Å

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsMEMBRANE PROTEIN / complex / IR / apo-form / s661 / antagonist / insulin mimetic

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