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Structure paper

TitleStructural basis for activation and potentiation in a human a5b3 GABAA receptor
Journal, issue, pagesTo Be Published
Publish dateNov 2, 2024 (structure data deposition date)
AuthorsCowgill J / Fan C / Howard RJ / Lindahl E
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.14 - 3.81 Å
Structure data

51980

9haa

EMDB-51980, PDB-9haa:
a5b3 GABAA Receptor resting state
Method: EM (single particle) / Resolution: 3.14 Å

52312

9hnq

EMDB-52312, PDB-9hnq:
a5b3 GABAA Receptor bound to GABA and Mb25 in desensitized state in detergent micelles
Method: EM (single particle) / Resolution: 3.81 Å

Chemicals

ChemComp-BUA:
butanoic acid

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-ZN:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-ABU:
GAMMA-AMINO-BUTANOIC ACID / neurotransmitter, inhibitor*YM

Source
  • homo sapiens (human)
  • escherichia coli (E. coli)
  • aequorea victoria (jellyfish)
KeywordsMEMBRANE PROTEIN / GABA receptor / pentameric ligand gated ion channel / cys-loop receptor

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