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-Structure paper
Title | Divergence of quaternary structures among bacterial flagellar filaments. |
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Journal, issue, pages | Science, Vol. 320, Issue 5874, Page 382-385, Year 2008 |
Publish date | Apr 18, 2008 |
![]() | Vitold E Galkin / Xiong Yu / Jakub Bielnicki / John Heuser / Cheryl P Ewing / Patricia Guerry / Edward H Egelman / ![]() |
PubMed Abstract | It has been widely assumed that the atomic structure of the flagellar filament from Salmonella typhimurium serves as a model for all bacterial flagellar filaments given the sequence conservation in ...It has been widely assumed that the atomic structure of the flagellar filament from Salmonella typhimurium serves as a model for all bacterial flagellar filaments given the sequence conservation in the coiled-coil regions responsible for polymerization. On the basis of electron microscopic images, we show that the flagellar filaments from Campylobacter jejuni have seven protofilaments rather than the 11 in S. typhimurium. The vertebrate Toll-like receptor 5 (TLR5) recognizes a region of bacterial flagellin that is involved in subunit-subunit assembly in Salmonella and many other pathogenic bacteria, and this short region has diverged in Campylobacter and related bacteria, such as Helicobacter pylori, which are not recognized by TLR5. The driving force in the change of quaternary structure between Salmonella and Campylobacter may have been the evasion of TLR5. |
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Methods | EM (helical sym.) |
Structure data | ![]() EMDB-5007: |
Source |
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