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-Structure paper
タイトル | Divergence of quaternary structures among bacterial flagellar filaments. |
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ジャーナル・号・ページ | Science, Vol. 320, Issue 5874, Page 382-385, Year 2008 |
掲載日 | 2008年4月18日 |
著者 | Vitold E Galkin / Xiong Yu / Jakub Bielnicki / John Heuser / Cheryl P Ewing / Patricia Guerry / Edward H Egelman / |
PubMed 要旨 | It has been widely assumed that the atomic structure of the flagellar filament from Salmonella typhimurium serves as a model for all bacterial flagellar filaments given the sequence conservation in ...It has been widely assumed that the atomic structure of the flagellar filament from Salmonella typhimurium serves as a model for all bacterial flagellar filaments given the sequence conservation in the coiled-coil regions responsible for polymerization. On the basis of electron microscopic images, we show that the flagellar filaments from Campylobacter jejuni have seven protofilaments rather than the 11 in S. typhimurium. The vertebrate Toll-like receptor 5 (TLR5) recognizes a region of bacterial flagellin that is involved in subunit-subunit assembly in Salmonella and many other pathogenic bacteria, and this short region has diverged in Campylobacter and related bacteria, such as Helicobacter pylori, which are not recognized by TLR5. The driving force in the change of quaternary structure between Salmonella and Campylobacter may have been the evasion of TLR5. |
リンク | Science / PubMed:18420936 |
手法 | EM (らせん対称) |
構造データ | EMDB-5007: |
由来 |
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