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TitleMicrobiota-derived secondary bile acids promote STING activation and antitumor activity
Journal, issue, pagesTo Be Published
Publish dateFeb 5, 2025 (structure data deposition date)
AuthorsYang X / Zhang X / Li W / Gharpure A / Hansel A / Tillack A / Wu C / Hsieh Y / Sulpizio A / Dikiy S ...Yang X / Zhang X / Li W / Gharpure A / Hansel A / Tillack A / Wu C / Hsieh Y / Sulpizio A / Dikiy S / Zhao X / Forli S / Ward AB / Parker CG / Hang HC
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.93 Å
Structure data

49094

9n7f

EMDB-49094, PDB-9n7f:
HsSTING with cGAMP/C53/DCA
Method: EM (single particle) / Resolution: 2.93 Å

Chemicals

ChemComp-9IM:
1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide

ChemComp-1SY:
cGAMP

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Innate immunity / membrane protein

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